How We Organize Our Data

We aim to document our experiments transparently and thoroughly, and we attempt to design experiments that improve reproducibility. This glossary defines the terms that are required to understand the data structure and reproduce the experimental design.


Investigative Unit(s): This is the smallest set of self-contained experimental units where multiple dishes of a single cell line (thawed and cultured at the same time) are treated with an FDA approved drug and/or drug combinations. Metadata for these individual investigative units are displayed under enumerated by treatment date. For example, investigative unit U-17 comprised 24 dishes of PromoCell cardiomyocytes, Line B. These dishes were treated with 19 different FDA approved drugs or drug combinations on 03/27/15.


Sample(s): Each dish within a single investigative unit is considered an individual sample, and is assigned a unique sample identifier.


Sequencing Run(s): We collate multiple investigative units in a single 96- or 384-well plate to generate a cDNA library using the unique molecular identifier (UMI) tagging system. Samples from different plates are compared for consistency, reproducibility, and any potential biases or batch effects. For example, a 96-well plate for sequencing run SR-2 was prepared on 04/01/15. It comprises 96 samples from 6 investigative units, 25 different drugs and drug combinations, and 3 cell lines.


Sample Identifier: Our sample identifiers are based on the treatment condition and the well location of the specific sequencing run in which it was characterized. For example, amiodarone (AMI) treated sample from investigative unit 17 was located in sequencing run SR-2, well number H5. It is therefore labeled as AMI.2.H5.


Experimental Unit(s): An experimental unit comprises a group of samples treated with one or more FDA approved drugs and their appropriate vehicle-treated controls that have passed QA/QC. Experimental units contain multiple biological replicates, and they are parsed between multiple sequencing runs; concurrently, each sequencing run includes parts of multiple experimental units. This mix and match format is intended to reduce batch effects during library preparation and sequencing.

data explanation image

For further details see Standard Operating Procedures »

Release Date: June 30, 2015
Cell Lines: PromoCell Cardiomyocyte, Line A (LPC-1001);Line B (LPC-1002); Line D (LPC-1003)
Details: Raw FASTQ files for sequencing runs SR-1 and SR-2.
Investigative Units: U-2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17
Sequencing Runs: SR-1,2
Download: Request Data
Release Date: June 30, 2015
Cell Lines: PromoCell Cardiomyocyte, Line A (LPC-1001);Line B (LPC-1002); Line D (LPC-1003)
Details: Complete unique molecular identifier counts for sequencing runs SR-1 and SR-2.
Investigative Units: U-2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17
Sequencing Runs: SR-1,2
Download: Raw-Data-R2015-06-30
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Alendronate (ALE)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: ALE.1.F7, ALE.1.F8, ALE.1.G10
Investigative Units: U-7, 8, 4, 5, 6
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-ALE.txt
Enrichrment Analysis: Analyze UP genes with Enrichr Enrichr Logo Analyze DOWN genes with Enrichr Enrichr Logo
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 VIM 1.012290576 11.30411519 4.53289260e-22
2 RPS21 0.570737514 10.49035133 3.19365948e-10
3 RPL10A 0.541489238 11.42917240 2.41056685e-08
4 MTHFD2 0.547273456 8.76719064 4.72328988e-06
5 TSLP 1.125491873 3.94162744 8.35840964e-06
6 RPL7A 0.425409874 11.12298955 9.00129188e-06
7 RPS4X 0.392492392 11.96149305 1.03684943e-05
8 RCAN1 0.878960892 4.74167400 1.59887728e-05
9 TNFAIP6 0.582924639 7.65081688 2.31539684e-05
10 GPR1 0.548145689 6.72727978 3.43255090e-05
11 CREB3L4 1.343118513 2.83643884 5.70508750e-05
12 FAM98A -0.747395790 6.03018707 7.12259305e-05
13 ALKBH7 0.848778651 4.48925490 1.00793720e-04
14 LBH 0.589935743 7.45017463 1.19698524e-04
15 BOD1L1 -0.836793851 5.43188334 1.30570375e-04
16 THBS1 -0.433595440 9.40046027 1.74759212e-04
17 PPP3CA -0.669430317 5.58800223 1.75179562e-04
18 AHNAK -0.504543924 8.12489178 1.79288936e-04
19 STK17B -0.553738497 6.90692685 1.80162656e-04
20 HERPUD1 0.498827436 6.60462951 2.01786335e-04
21 MLEC -0.693627354 5.40162233 2.03652861e-04
22 PAFAH1B2 -0.585842590 6.57231614 2.32537996e-04
23 CDR1 0.504881250 7.03012235 2.46602658e-04
24 SMARCA5 -0.619146638 5.85493286 2.65926707e-04
25 WNK1 0.518978844 6.28902558 2.66817471e-04
26 MARCKS -0.456427635 7.99698417 2.92427968e-04
27 UAP1 0.479426019 6.67107655 3.09229627e-04
28 TARS 0.451819897 7.50437181 3.09288717e-04
29 CCL11 0.462734301 6.56661308 3.58430831e-04
30 CD200 0.550483417 5.77125543 3.85776425e-04
31 EIF2AK1 -0.947837547 4.53123583 4.48849919e-04
32 HMGB2 0.459928353 7.55092264 4.70145507e-04
33 RAC1 -0.542978334 7.38399979 4.78157407e-04
34 RPS27A 0.342083276 12.26653749 4.97612948e-04
35 ENTPD7 -1.645347624 3.23017406 5.23998168e-04
36 DDX3X -0.505566336 6.54641376 5.27963963e-04
37 GOLGA4 -0.541813353 7.19105083 5.59633435e-04
38 PDLIM3 0.432339626 6.80722735 5.88190121e-04
39 MSC 0.694335465 4.78738077 6.11689032e-04
40 PRSS23 -0.410159180 8.26735110 6.23914034e-04

Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Amiodarone (AMI)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: AMI.2.C6, AMI.2.C7, AMI.2.D11
Investigative Units: U-10, 11, 4, 5, 6, 7, 8
Sequencing Runs: SR-2,1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-AMI.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL27A -1.553936476 11.31517503 1.13646208e-52
2 RPL18A -1.433072072 12.04311068 2.31792420e-52
3 ALDOA -1.711292173 9.91380899 2.76755091e-52
4 RPLP2 -1.510688123 11.61148515 3.55560023e-51
5 MMP1 2.595181430 4.19475919 2.67247458e-49
6 NDUFA11 -1.570039876 8.60617113 5.97541066e-48
7 TECR -2.077687686 6.76119082 3.16544538e-44
8 FABP4 -4.375505213 5.08255974 7.94594347e-35
9 EIF4G2 1.143621941 8.00372692 1.57812598e-34
10 MEG3 1.358573866 7.61337420 1.95383079e-32
11 RAB12 1.259800080 6.17831800 3.11353863e-30
12 RHOC -1.256237006 7.72962563 3.28326641e-29
13 TAGLN -1.092186013 11.09060642 4.92882888e-29
14 ABCA1 1.591182215 8.10573431 8.94026781e-28
15 TUBA4A -1.625563465 6.11006012 3.77912485e-27
16 MDH2 -1.269480369 7.73056628 9.76361015e-27
17 FIBP -1.505713300 6.46265287 2.32156987e-26
18 A2M 2.230973556 3.62770433 4.74979793e-26
19 SRSF6 1.254560806 6.52146191 1.96393167e-25
20 PTRHD1 -1.536764779 6.33499993 2.50054666e-25
21 NDUFA13 -1.064333606 8.99198064 6.97745715e-25
22 ATP5B -1.088825998 8.21422350 1.50341931e-23
23 HSPA1B -3.542862866 4.05369598 3.63641544e-23
24 CSRP1 -1.049505600 8.49938459 9.27667963e-23
25 SNRNP27 -1.326894519 6.59935080 1.59713250e-22
26 RPS14 -0.914072639 12.72446541 3.19571023e-22
27 SH3BGRL3 -0.904874804 9.45229621 1.28257073e-21
28 PSMD6 -1.289080937 6.48058251 1.54815618e-21
29 NUTF2 -1.160023279 7.23834161 2.24618575e-21
30 ACTG1 -0.979702101 11.70028125 1.01116433e-20
31 NDUFA3 -0.995726441 7.77710872 1.59318012e-20
32 SNHG17 -1.349963278 6.08065133 2.49444079e-20
33 HIST1H2BK -1.394785708 6.00131922 2.74016646e-20
34 PPP1R7 -1.430186870 6.11702454 3.75605068e-20
35 POLR2F -1.140493297 6.93718106 6.78474662e-20
36 PPP2R1A -1.402221502 6.00426644 6.82391918e-20
37 NNMT -1.109672251 9.91271718 1.62965593e-19
38 LAMTOR4 -1.037970054 7.82517551 2.26958654e-19
39 SNHG6 -1.085043087 7.27737838 6.21939425e-19
40 MARCH6 1.073544178 5.95687430 1.01489697e-18

Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Diclofenac (DIC)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: DIC.1.G5, DIC.1.G6, DIC.2.C11
Investigative Units: U-8, 10, 4, 5, 6, 7
Sequencing Runs: SR-1,2
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-DIC.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 JUND 1.463212976 4.93946393 1.39503701e-12
2 PLIN2 1.111666542 7.51869322 9.07329322e-09
3 MT2A 0.715857993 9.12613320 8.96260042e-08
4 HBB -5.534826095 6.61799895 1.13455720e-07
5 RPS27A 0.622797975 12.34158720 5.93667476e-07
6 JDP2 1.362051438 3.70204316 1.96161927e-06
7 SERPING1 0.667749154 6.15314545 3.65466720e-06
8 PPP1R15A 1.052726131 4.49494100 8.38683047e-06
9 SNHG1 1.150084226 3.77383511 9.12534146e-06
10 ARL4A -0.870145715 5.08713588 9.84245664e-06
11 PRSS23 -0.567309538 8.25067088 1.05276923e-05
12 VCAN -0.560498651 9.46518208 1.67086778e-05
13 HSPA1B 1.309450153 4.69490554 2.94012417e-05
14 HMGB2 0.618850603 7.59844723 3.01488845e-05
15 ATXN2L 1.391963728 3.00372949 3.75356008e-05
16 INHBA -0.532671319 7.62998978 4.50858043e-05
17 COL12A1 -0.622486348 7.77701925 4.51470331e-05
18 AHNAK -0.649672148 8.11000179 5.15099377e-05
19 DNAJB1 0.932941168 5.03764405 5.33604719e-05
20 CSRP1 -0.473759117 8.56372606 6.63397168e-05
21 SCARF2 0.907557874 4.59153604 6.72680341e-05
22 KRT7 -0.870408952 4.90373607 7.29968519e-05
23 BMPR2 -0.740815601 5.62845453 7.57589510e-05
24 LRIG1 -2.125640864 2.76408833 7.68419030e-05
25 TMOD3 -0.512763311 7.67171230 9.34418766e-05
26 MEG3 0.676241364 7.38175327 9.52087305e-05
27 LRP1 0.527025898 6.79484415 9.79836394e-05
28 OSTF1 -0.906826730 4.83393442 1.01887293e-04
29 LGR4 -1.043830260 4.56268292 1.14343065e-04
30 APOE 1.503779180 2.38612569 1.26385071e-04
31 SCG2 0.701826267 6.24077841 1.45308597e-04
32 FAM46C -1.230186978 3.67521230 1.57318724e-04
33 LOXL2 0.464806465 7.59215741 1.76367562e-04
34 PCSK6 -0.708796729 5.41604854 1.79477837e-04
35 SCG5 0.886013734 3.95792679 1.81098972e-04
36 SOD2 0.583225579 5.72332466 2.02889103e-04
37 ANXA3 0.972629454 3.74479076 2.05738771e-04
38 H19 -0.753043719 5.27288331 2.12016548e-04
39 LINC00847 0.956729674 3.58915892 2.16034034e-04
40 GDF6 -0.932252490 4.51811492 2.30774768e-04

Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Domperidone (DOM)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: DOM.1.B7, DOM.1.B8, DOM.1.C7
Investigative Units: U-4, 5, 6, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-DOM.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 VIM 0.429802196 11.15388967 3.43300657e-06
2 HSD17B14 2.160996549 1.63851754 7.74242848e-05
3 ZNF449 1.285060979 2.79731191 1.10740804e-04
4 FKBP9L -4.930045302 2.00578089 1.69529933e-04
5 MYH11 1.000724843 3.66184338 2.53593980e-04
6 PITPNA 0.777179813 4.13605218 3.42284125e-04
7 PRUNE2 0.851584817 3.66475139 3.64393790e-04
8 RNLS 1.106043614 2.95507739 3.76068425e-04
9 ANTXR2 0.480125214 6.14863747 4.42927257e-04
10 KDM5B 0.508340188 5.65972369 6.05573360e-04
11 PIWIL3 -3.052550799 2.09560747 7.41949282e-04
12 GNG2 -1.780235445 2.82667672 8.07998421e-04
13 LINC00883 -1.214445338 3.66720438 1.15852963e-03
14 SNX17 -0.754344234 4.64876735 1.22057108e-03
15 THAP4 -1.538640882 3.08926849 1.37662137e-03
16 POLD2 -0.621520300 5.06017294 1.49370146e-03
17 JAKMIP2 -2.434008624 2.22338564 1.56397911e-03
18 COL14A1 0.448820531 7.39183853 1.93212685e-03
19 SF3A1 0.773660354 3.67828100 1.98948682e-03
20 SFI1 1.809270730 1.69002383 2.08300993e-03
21 DCAF6 0.585829082 4.74118995 2.12031572e-03
22 PCOLCE2 -1.485335844 2.91234879 2.22477313e-03
23 PTPN18 -1.833116915 2.66502199 2.26599060e-03
24 WDR52 -1.819439844 2.65848963 2.36866806e-03
25 LBR 0.770699399 3.64824814 2.76557015e-03
26 SULT1C2 2.116588149 1.43931130 2.82836280e-03
27 INPP5B -1.255137068 3.10103688 2.86559778e-03
28 DCHS1 -4.384933429 1.69701624 3.37285678e-03
29 ZFP91 0.605599987 4.46665296 3.41054100e-03
30 IFI27L2 -0.439428246 6.48019452 3.49184578e-03
31 NIF3L1 -0.652868585 4.71998565 3.73018554e-03
32 MRPS31P5 -1.446598754 2.88781139 3.73223464e-03
33 TLN1 0.395767846 6.20032774 3.91132259e-03
34 ACAP2 0.416348684 5.61836056 4.05433514e-03
35 CSRNP2 0.903670568 3.14140533 4.13710301e-03
36 RPS6KA3 -0.748948242 4.21313521 4.17780766e-03
37 HBP1 -1.131142259 3.20990269 4.23037334e-03
38 FUNDC1 -0.613165292 4.83377701 4.37776813e-03
39 PRKAR1A 0.356170013 6.88126698 4.61290930e-03
40 FIBIN 0.558255721 4.61240679 4.65179360e-03

Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Diethylpropion (DTP)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: DTP.1.E11, DTP.1.E12, DTP.1.G3
Investigative Units: U-7, 8, 4, 5, 6
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-DTP.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 NSA2 1.198545858 7.29043206 1.44484800e-15
2 RPS9 0.945424060 9.68327298 6.17966332e-15
3 WNK1 0.762991176 6.35832317 6.74148454e-08
4 MSC 0.910862884 4.86082627 6.40178313e-07
5 VIM 0.473343247 11.15839120 1.65179757e-06
6 TNFRSF1A 0.792243306 4.91655351 1.95723896e-06
7 RPL18 0.572641334 8.49366209 3.35347872e-06
8 C12orf57 0.453618583 8.87661526 3.62923514e-06
9 KLF10 0.708855665 5.21887589 4.99403040e-06
10 FABP4 -1.423961097 5.22622076 8.21380164e-06
11 CCL11 0.522531510 6.59291750 1.03079049e-05
12 RPL28 0.473973660 10.39544940 2.04217945e-05
13 HMGB2 0.612795980 7.59501110 3.13289635e-05
14 SAA1 -3.580077346 2.76985018 3.97792506e-05
15 VEGFA 0.564794005 6.23490367 4.09526760e-05
16 SLFN5 0.663867362 5.21486241 4.45518436e-05
17 BHLHE41 0.584488527 6.95359561 4.73953771e-05
18 ZNHIT1 -0.577073752 6.28281744 1.14745150e-04
19 MYPOP -1.530787870 3.12410060 1.27730342e-04
20 RAC1 -0.604748229 7.37675206 1.95763306e-04
21 SERPING1 0.519297159 6.11581278 2.14886718e-04
22 PITPNA 0.756923491 4.13139600 2.39014053e-04
23 ANTXR2 0.509499297 6.14750382 3.16956189e-04
24 PTK2B 1.523855491 2.01240559 3.27334156e-04
25 WNT3 2.279129116 1.35387373 4.27367121e-04
26 PNO1 0.849484220 3.41973546 4.57308141e-04
27 ARRDC3 0.519608862 5.58926312 4.60004681e-04
28 PPP3CA -0.561929450 5.59836965 5.73272229e-04
29 HJURP -2.941753268 1.83244790 6.18475027e-04
30 JUND 0.673111557 4.69219707 6.80296597e-04
31 TNFRSF12A -0.576787271 5.26730756 7.31468439e-04
32 KAT7 -1.421768608 2.95933483 7.56138538e-04
33 EGR1 -1.252385218 3.28691254 8.56520772e-04
34 PLIN1 -4.808113732 1.83879984 8.62437636e-04
35 GPCPD1 1.103823235 3.15287244 8.63648306e-04
36 CBR1 -0.472140176 6.58795305 9.37971366e-04
37 CCL2 0.483330906 7.78151503 1.07291839e-03
38 ACBD3 -0.681362087 5.08207240 1.12360458e-03
39 F8 1.056556424 2.84026879 1.17420870e-03
40 CHORDC1 -0.808431369 4.20836501 1.19002602e-03

Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Entecavir (ENT)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: ENT.1.D5, ENT.1.D6, ENT.1.D7
Investigative Units: U-6, 4, 5, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-ENT.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 FABP4 -1.703838561 5.23482476 5.19317363e-10
2 RBM3 0.780286599 7.84115571 8.14072556e-09
3 CRYAB -0.592300177 9.14632616 5.01972474e-07
4 ITM2B 0.549697293 8.16014314 5.19768073e-07
5 HBB -3.347790904 6.67629892 1.72417161e-06
6 CCL2 -0.769216005 7.57725488 2.32455187e-06
7 S100A4 -0.663897491 9.65443804 2.84366913e-06
8 NTM 0.673231175 6.13478822 3.42719030e-06
9 TMEM138 -0.795614920 5.59608716 2.28670335e-05
10 HSPA8 -0.423264016 9.58533341 2.31448338e-05
11 MGP -0.487724838 10.20435751 2.39378283e-05
12 ID2 -0.615494922 8.02809162 3.11489355e-05
13 PSMB6 0.451151322 7.93019524 4.88398185e-05
14 TBC1D22A 1.383251934 2.71980680 5.42970797e-05
15 MT2A 0.470828709 9.07294893 7.19202050e-05
16 VCAM1 -1.040297200 5.00054215 7.64296183e-05
17 EFEMP1 -0.398803442 10.69352535 9.04734149e-05
18 IFITM1 -0.828314524 5.53933289 9.71320523e-05
19 XPO1 -0.845436970 4.97697485 1.24256954e-04
20 NIT1 -0.950633965 4.72635812 1.48866037e-04
21 CSRP2 -0.624252689 6.22349428 2.18707023e-04
22 TMEM216 -0.753328422 4.97282710 2.37614655e-04
23 LUM -0.472129444 9.67072587 2.38564527e-04
24 PYCARD -3.093527638 2.29466234 2.75187656e-04
25 GGT8P 1.420914128 2.47191148 3.14845633e-04
26 S100A13 -0.402946607 8.67135623 3.35761659e-04
27 FBLN1 -0.812819781 5.12328753 3.36733715e-04
28 COL15A1 -0.643293184 6.11865630 3.86733266e-04
29 UHRF1BP1L 0.815366780 4.11162216 4.59906858e-04
30 ZSCAN32 -1.222871490 3.59308607 4.85025070e-04
31 F5 1.685514531 1.92604120 4.96510083e-04
32 DNMT1 -1.172293945 3.88168858 5.13761075e-04
33 RGS5 -0.601053957 5.97963140 5.18239762e-04
34 GINS3 1.803530207 1.74213156 5.99209356e-04
35 SENP8 -3.173557932 2.35071501 6.57453682e-04
36 IL6 -0.708511776 5.27622282 6.74337231e-04
37 IFITM2 -0.423739208 8.53509716 7.20342195e-04
38 PPP6C -0.483738970 6.50824309 7.57328969e-04
39 BAMBI -1.236524636 3.69836035 7.67887878e-04
40 KPNA5 -2.548442467 2.49680537 8.04428224e-04

Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Flecainide (FLE)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: FLE.2.C8, FLE.2.C9, FLE.2.D12
Investigative Units: U-10, 11, 4, 5, 6, 7, 8
Sequencing Runs: SR-2,1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-FLE.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 TECR -2.193556702 6.74305287 2.07007876e-55
2 RPLP2 -1.565603959 11.60652777 1.25273560e-50
3 ALDOA -1.668412593 9.91520864 5.76301085e-50
4 RPL27A -1.578393399 11.31251108 6.67839441e-50
5 MMP1 2.523052803 4.20045906 7.27989776e-50
6 RPL18A -1.361335510 12.04816817 1.34495337e-44
7 NDUFA11 -1.486408506 8.61002750 8.11266050e-43
8 ABCA1 1.790556702 8.19371607 5.61037877e-39
9 SRSF6 1.479620491 6.61146189 1.04392468e-37
10 FABP4 -3.875722729 5.05941189 8.56738678e-36
11 TUBA4A -1.809551735 6.08435252 1.09851522e-35
12 EIF4G2 1.150661914 8.00747789 3.55514151e-35
13 RAB12 1.296366107 6.19334133 6.18143178e-34
14 TAGLN -1.292221566 11.07170278 8.70376333e-33
15 RHOC -1.267510405 7.72439350 4.50347140e-31
16 FAU -1.313254635 8.90559105 8.79153387e-31
17 A2M 2.252788882 3.68530405 2.43108143e-30
18 FIBP -1.484155557 6.44873271 3.52989179e-30
19 MEG3 1.261353857 7.57974074 2.90859288e-29
20 MDH2 -1.275576337 7.72714091 1.07489983e-27
21 PSMD6 -1.388363740 6.45859678 3.72930408e-27
22 PTRHD1 -1.453574568 6.32885358 9.21064347e-27
23 PTEN 1.301800851 6.12054789 1.90941228e-26
24 ATP5B -1.176843603 8.20324374 2.20434082e-26
25 NDUFA13 -1.111577155 8.98509090 3.12002833e-26
26 CSRP1 -1.213346348 8.48263466 3.40770283e-26
27 NUTF2 -1.256875961 7.22262135 1.89391689e-25
28 HSPA1B -2.856789106 4.01762675 7.52788052e-25
29 C6orf62 1.224864338 7.29590703 4.26970975e-24
30 NDUFA3 -1.077573545 7.76481529 5.28712775e-24
31 C12orf10 -1.372393485 5.67784526 2.47769023e-23
32 PPP2R1A -1.436359212 5.98716830 2.82369959e-23
33 POLR2F -1.203820345 6.92483723 5.86821523e-23
34 SNHG17 -1.316358459 6.06839682 2.29812433e-22
35 ACTG1 -1.084504934 11.68904780 3.48244517e-22
36 MARCH6 1.174309687 5.99470715 4.58545753e-22
37 PPP1R7 -1.352196172 6.10907958 1.45911316e-21
38 RNASEK -1.526525097 5.15238033 1.50249293e-21
39 SH3BGRL3 -0.916628949 9.44963210 2.03845337e-21
40 PRR13 1.021543548 6.70865933 7.31104210e-21

Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Imatinib (IMA)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: IMA.1.H4, IMA.2.C1, IMA.2.D8
Investigative Units: U-8, 10, 11, 4, 5, 6, 7
Sequencing Runs: SR-1,2
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-IMA.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RGS5 1.249965757 6.38649124 1.56918697e-20
2 MMP1 2.020396546 3.85658350 2.51128156e-14
3 DDAH1 0.855174849 6.47757111 1.16582128e-11
4 MEG3 1.019854984 7.48925064 1.39286039e-11
5 PSG5 1.581860286 3.50118170 2.75521177e-11
6 A2M 1.770897565 3.36129664 2.08353442e-10
7 EIF4G2 0.814143618 7.89638477 1.85087217e-09
8 SRSF6 0.872787644 6.38909002 1.86940324e-09
9 TECR -1.181698076 6.83568865 2.84457753e-09
10 PPP2R1A -1.069581440 6.05249613 7.00371247e-09
11 RNASEK -1.291828124 5.23022219 8.64184732e-09
12 HIST1H2BK -0.999374779 6.05382333 1.04866529e-08
13 RAB12 0.895275478 6.04426013 1.07481246e-08
14 MESDC2 -0.823968298 7.22538217 4.02310364e-08
15 FABP4 -1.975730299 5.19335531 4.16534943e-08
16 OCLN 1.154370208 4.13998549 4.94974471e-08
17 PRELID2 1.065899279 3.99604163 6.28150386e-08
18 SNHG6 -0.818021715 7.31251263 7.54324740e-08
19 COL14A1 -0.959547737 7.16191553 1.17265004e-07
20 SYNM -1.228867734 4.95346683 1.35534120e-07
21 RPS15 0.695854247 9.97859398 1.49004293e-07
22 PSMD6 -0.852613340 6.53690435 3.50537159e-07
23 ACIN1 -0.891858982 5.92534044 3.55797093e-07
24 LMAN1 -0.744146891 8.28267733 4.76231208e-07
25 SNHG17 -0.909206631 6.14100314 5.88540518e-07
26 CAP1 0.553289812 8.03454635 5.96458981e-07
27 PCBP2 -0.691777004 6.94818095 6.97652849e-07
28 ARPC4 -0.769183226 6.17327403 8.12042033e-07
29 SFXN3 0.896811632 4.60680598 8.13780716e-07
30 POLE3 -0.766564428 6.46063269 8.66572953e-07
31 ANXA10 3.246257343 1.35499929 9.30702623e-07
32 ANXA2 0.492310160 11.22447199 9.35612096e-07
33 PHPT1 -0.633260808 9.67976111 1.01692382e-06
34 CHD6 -1.071174508 5.27858622 1.32325765e-06
35 COPE 0.888256124 4.66926108 1.35900856e-06
36 SPTAN1 -0.755538279 6.15082538 1.38601710e-06
37 SNRNP27 -0.846193594 6.66053286 1.42868582e-06
38 PLIN2 0.717584114 7.40749851 1.70319790e-06
39 AMOTL1 -1.070795246 4.69765297 1.92428542e-06
40 MIF 0.537910705 7.72310915 2.14277306e-06

Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Loperamide (LOP)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: LOP.1.B2, LOP.1.B3, LOP.2.D6
Investigative Units: U-4, 11, 5, 6, 7, 8
Sequencing Runs: SR-1,2
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-LOP.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RGS5 0.863569490 6.26227537 5.17164930e-07
2 TLK1 0.675697380 5.40780341 7.60883169e-06
3 HBB -3.692508542 6.64885598 1.47949839e-05
4 EXOSC5 -1.225752333 4.41033836 1.71768704e-05
5 MARCH6 0.626879562 5.82006464 4.41044971e-05
6 POLR2F -0.607680629 7.01168199 5.27923147e-05
7 LDLR 0.868766785 4.27870201 9.12483155e-05
8 ASAP2 0.671660179 4.90085302 1.26312103e-04
9 C6orf62 0.547825280 7.08997681 1.97613905e-04
10 SRSF6 0.575367267 6.31048939 2.01681805e-04
11 PGM2 -2.219715947 2.59574964 2.31504716e-04
12 FLNA 0.512494651 5.82788476 2.41519820e-04
13 SWI5 -0.571665453 6.27533356 2.80003980e-04
14 ID2 -0.612368052 8.02434613 2.80488799e-04
15 ABCA1 0.613888940 7.78073920 3.28968255e-04
16 C3orf58 0.784423646 4.54031319 3.44152600e-04
17 DDAH1 0.487462966 6.38265335 4.25209809e-04
18 EIF4G2 0.467945935 7.80750699 4.39697084e-04
19 MXD3 2.961974244 1.17929173 5.19222309e-04
20 SORT1 0.617664437 4.84105255 5.39750064e-04
21 MEG3 0.570880018 7.36380051 5.54301970e-04
22 STK17B 0.484670407 7.11102380 5.77341211e-04
23 LOC284950 1.213056550 2.42013870 6.46971243e-04
24 LTB4R 2.227750416 1.30171269 6.51930754e-04
25 CSTF3 -0.868154904 4.60852936 7.59612821e-04
26 ZNF765 0.987849377 3.18410530 7.97480469e-04
27 FAM135A 1.531811264 1.90636985 8.29402153e-04
28 MMP1 1.153477369 3.51938026 8.29895905e-04
29 USP39 -0.751538833 4.65616947 8.53760826e-04
30 DDIT4 0.778620749 4.94670253 8.59890069e-04
31 PPP1R10 -0.698024549 4.95693474 8.62218792e-04
32 BCAR3 1.102107549 2.72446681 9.19071050e-04
33 PTRHD1 -0.524591772 6.45614918 1.02364339e-03
34 NNMT -0.440079865 9.99508437 1.05475632e-03
35 EML3 1.325487696 2.56171866 1.06583020e-03
36 PIGV -1.136625599 3.58051672 1.09016622e-03
37 JAG1 0.572067923 4.93558851 1.12115191e-03
38 TRAPPC2 0.607451517 5.02372367 1.13213306e-03
39 PPP1CB 0.368157300 7.87733830 1.16776273e-03
40 HIST1H1C -0.484259035 6.66462214 1.32972054e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Paroxetine (PAR)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: PAR.1.G12, PAR.1.H1, PAR.2.D3
Investigative Units: U-8, 10, 4, 5, 6, 7
Sequencing Runs: SR-1,2
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-PAR.txt
>
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 MEG3 1.064046483 7.50599866 9.93267921e-11
2 RPL18 1.247727446 8.70702729 7.52698897e-10
3 GPR1 0.742264139 6.79825590 1.18312510e-08
4 SLFN5 0.850301818 5.28587569 1.57386881e-08
5 TRIB3 0.976530733 4.68166500 3.98588082e-07
6 MTHFD2 0.647247645 8.80934442 4.22601421e-07
7 TNFAIP6 0.727851736 7.70690555 5.45411223e-07
8 PLK2 -0.787829943 6.15548019 9.68020871e-07
9 RCAN1 0.916779830 4.78239743 3.00087149e-06
10 GPR78 2.073093572 2.12588104 3.73408953e-06
11 ENDOD1 -1.391294227 3.92057147 5.10559482e-06
12 C15orf48 1.335343344 3.35420755 7.08788046e-06
13 C21orf62 0.806152711 4.84274223 7.57299265e-06
14 RB1 -1.418856965 3.99170598 9.47165739e-06
15 KCTD12 -1.113075617 4.35935656 1.58996732e-05
16 GOT1 0.686086425 6.24777756 2.00903040e-05
17 RGS5 0.577866232 6.18341788 2.09285894e-05
18 NEAT1 0.789110665 4.78614253 2.46603513e-05
19 CCL11 0.513846824 6.59975093 2.68620879e-05
20 PRR13 0.585244123 6.57687711 3.06869627e-05
21 RAB36 0.992395356 3.93166074 3.09891598e-05
22 APC -0.831445790 5.15066980 3.41281825e-05
23 MGP -0.515377663 10.19788830 5.15580950e-05
24 PDE7A 0.950535277 4.19981624 5.28690461e-05
25 HMOX1 1.147240642 3.13643727 6.24230795e-05
26 RAC1 -0.686077466 7.38095458 6.26821828e-05
27 BIN3 -0.970531596 4.68687191 7.16033160e-05
28 PSME3 0.924873270 3.90474786 8.00246387e-05
29 PCBD2 0.953923535 3.81939227 8.33331821e-05
30 A2M 1.320857504 3.19734666 8.50807023e-05
31 VSTM4 0.883103617 3.93101299 1.03795405e-04
32 LDLR 0.838852935 4.26884074 1.08255202e-04
33 LOXL2 0.487901176 7.60811759 1.08906560e-04
34 ASNS 0.519432119 7.18812419 1.09798445e-04
35 METTL20 1.283216223 2.96889874 1.10040459e-04
36 ABCA1 0.749900404 7.81650201 1.12995551e-04
37 APOBEC3A 1.071711853 3.20807878 1.15032320e-04
38 LOC284454 0.841406692 4.13623218 1.18542847e-04
39 CNTN4 1.333983691 2.58314807 1.34050697e-04
40 COL12A1 -0.562482765 7.79464010 1.41067265e-04
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sorafenib + Ursodeoxycholic acid (SOR+URS)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: SOR+URS.1.C3, SOR+URS.1.C4, SOR+URS.1.C5
Investigative Units: U-5, 4, 6, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-SOR+URS.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 HSPA1B 4.95695631 6.77866824 4.70315395e-253
2 DNAJB1 4.32801799 6.73563839 1.35868427e-206
3 HSP90AA1 2.69005216 10.08642966 4.74908707e-191
4 HSPA1A 4.54189926 5.74788981 6.59261809e-152
5 HSPH1 3.43627644 6.94374517 3.44349330e-136
6 HSPA6 7.28521290 3.96939685 3.87264785e-108
7 PRRC2C 2.17353203 7.63939469 6.15453799e-63
8 MAP1B 1.72641795 9.11170881 4.51487509e-61
9 BRD4 3.51892086 4.90944715 1.00332519e-59
10 ANP32B 2.18784251 6.60655158 4.41275827e-47
11 GNB5 2.96098836 5.01899128 1.68353529e-45
12 ACTA2 -1.59117114 12.19205902 2.33563270e-44
13 PPP1R15A 2.96721263 5.08314757 7.06244531e-44
14 KTN1 1.80894259 7.54137670 5.76777256e-43
15 CALD1 1.26538120 11.17893586 5.81920515e-42
16 FTL -1.49495587 14.50600556 2.35126421e-41
17 C5orf46 -1.85022576 9.45963310 4.56570254e-39
18 SCNM1 2.99840814 4.89249285 4.75982928e-39
19 RPS14 -1.33433801 12.79127001 2.44914082e-38
20 DUSP1 3.33996598 4.32475368 3.09859222e-38
21 MYL6 -1.32634369 12.15247115 5.64812502e-38
22 NDUFA4 -1.41140911 10.56809043 6.51429838e-38
23 PPIB -1.72540073 9.36568707 1.85860667e-37
24 LDHA -1.50342609 11.14127951 1.10794062e-36
25 RPS18 -1.28205341 13.11399543 2.01777331e-36
26 CDR1 1.67525701 7.45594539 4.70910496e-36
27 TMSB4X -1.31117730 13.57913139 5.74554840e-36
28 BAG3 2.65051807 5.05450359 9.93471010e-35
29 TPI1 -1.38717182 10.48512864 1.37829151e-34
30 TIMP1 -1.31844150 12.63789016 2.12737450e-34
31 OST4 -1.35389507 10.64507095 2.94286168e-34
32 OSTC -1.46311687 9.91988185 1.12370813e-33
33 RPLP0 -1.23726276 12.64556520 2.34051106e-33
34 RPS23 -1.35150909 12.78423273 2.66944998e-33
35 BIRC3 5.76172041 2.50509197 1.41809684e-32
36 SERF2 -1.25865604 11.76381334 1.74162940e-32
37 MFAP5 -1.41582020 10.10183799 1.91092335e-32
38 RAB12 1.95234234 6.39262259 3.13582677e-32
39 RPL15 -1.22215340 12.58395393 4.35641495e-32
40 SPARC -1.20463975 13.43772464 1.15896186e-31
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sunitinib (SUN)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: SUN.1.D2, SUN.1.D3, SUN.1.D4, SUN.1.F3, SUN.1.F4
Investigative Units: U-6, 7, 4, 5, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-SUN.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 MT2A 0.510116243 9.11584870 5.21015807e-07
2 VIM 0.451107904 11.19302764 6.34237884e-07
3 S100A4 -0.496992571 9.61894646 3.27740859e-05
4 SLN -0.690106135 5.36697751 6.13972223e-05
5 COL21A1 -0.890659359 4.91611910 9.36219280e-05
6 GPR1 0.385213631 6.73080902 1.19078797e-04
7 PRRX1 -0.584959691 4.90669181 1.59679588e-04
8 COL15A1 -0.502943675 6.06665074 1.61201970e-04
9 THBS1 -0.350532249 9.38456541 1.64407511e-04
10 TULP3 0.483840832 5.01915712 1.99782423e-04
11 RBM3 0.453121328 7.78572582 2.49518057e-04
12 SFPQ -0.491315379 5.27599190 2.64690266e-04
13 PIGG -1.000464093 3.08565274 2.75384591e-04
14 RPL22 0.310233353 10.80424642 3.02196187e-04
15 RAB31 0.313931134 7.06903069 3.38191506e-04
16 SH3BGR 0.321233616 8.72411435 3.52080857e-04
17 TDRD7 -1.625940478 2.31521581 4.06544907e-04
18 HAPLN1 0.347348430 7.70217682 4.21179759e-04
19 CCPG1 0.325516420 7.31624258 4.61912572e-04
20 LOC100506136 1.991711194 1.32007334 4.91390839e-04
21 SLC2A3 0.389458511 5.85817915 5.14610212e-04
22 PLP2 0.303919177 7.07027132 6.34658692e-04
23 ZFHX4 -0.746580247 4.12100018 7.41981577e-04
24 FBLN1 -0.482945856 5.08467465 8.24207876e-04
25 PI16 -1.210729687 2.71941498 8.47602496e-04
26 TNFSF4 1.125783105 2.27361233 9.38158068e-04
27 ABCB6 -0.825992098 3.49902304 9.73113587e-04
28 MLEC -0.465769271 5.38468516 1.00360895e-03
29 AHNAK -0.350419748 8.11733056 1.01419707e-03
30 MICA 0.398990296 5.18504868 1.03715373e-03
31 MANBA 0.445329919 4.93669792 1.10697151e-03
32 ALKBH7 0.501281296 4.46393996 1.18366889e-03
33 DARS 0.304742371 6.62081225 1.22768667e-03
34 RPS9 0.385014625 9.56694414 1.22799320e-03
35 APC -0.446997847 5.13832540 1.31384107e-03
36 NF1 -0.536717476 4.47354386 1.41790686e-03
37 TRERF1 -2.947240743 1.44474991 1.50463948e-03
38 FAM127B 0.435675018 4.80316700 1.59458325e-03
39 NT5DC2 -0.441770393 4.96860812 1.64320385e-03
40 C12orf52 -1.332586903 2.31015220 1.68063686e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sunitinib + Alendronate (SUN+ALE)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: SUN+ALE.1.F9, SUN+ALE.1.F10, SUN+ALE.1.G11
Investigative Units: U-7, 8, 4, 5, 6
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-SUN+ALE.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 VIM 0.869985498 11.26426879 2.71741850e-13
2 NSA2 1.000640166 7.22336201 1.02257108e-08
3 HMGB2 0.681380659 7.61156736 1.27060005e-07
4 NPR3 -0.601748131 7.42603654 5.83561315e-06
5 PPP3CA -0.848360106 5.57194630 6.11708591e-06
6 MT2A 0.524401702 9.07346458 1.23728078e-05
7 PRSS23 -0.508385969 8.25702419 1.63911155e-05
8 GOT1 0.627723406 6.22072162 2.26981837e-05
9 C12orf23 -0.716555935 6.54518320 3.19639885e-05
10 ACBD3 -0.934535448 5.06049878 3.41236331e-05
11 FAM98A -0.785191904 6.02796423 4.27124211e-05
12 THBS1 -0.461648017 9.40042123 5.83458425e-05
13 RPL13 0.387476474 10.08302550 7.13496042e-05
14 RPS15 0.515355606 9.92244775 7.70630058e-05
15 ZNF670-ZNF695 2.067036526 1.73389543 8.13718364e-05
16 S100A4 -0.568655043 9.65273754 9.42778820e-05
17 MTHFD2 0.454070657 8.74913066 1.32540551e-04
18 ACTB -0.414214754 10.50885218 1.37134758e-04
19 SLC3A2 0.673810842 5.05770796 1.44472838e-04
20 EIF4G1 -0.723653431 5.17276264 1.53723609e-04
21 ORMDL3 -0.756873061 5.10551755 1.65744037e-04
22 H19 -0.742279791 5.27593056 1.69755338e-04
23 STK17B -0.529193088 6.91155850 1.77740816e-04
24 ALKBH7 0.765715672 4.47827230 1.87710768e-04
25 GDF6 -0.899458501 4.52600384 2.01817403e-04
26 NAGLU -1.307864485 3.56027347 2.16051303e-04
27 ZNF737 0.895685643 3.87553857 2.45751239e-04
28 TPM2 -0.383727249 8.28504349 2.72132470e-04
29 ABCA6 0.719702312 4.41845169 2.92095315e-04
30 EXOSC6 0.949794303 3.72533108 3.00621633e-04
31 SLC36A2 1.088687010 3.12290197 3.11790986e-04
32 DHRS3 0.583979179 6.95116269 3.63137805e-04
33 ALMS1 1.335285065 2.53535039 3.87256793e-04
34 TAOK1 -0.638988491 5.62767644 4.04395812e-04
35 SLC4A1 2.194111018 1.49610018 4.38282417e-04
36 MARCKS -0.440973112 8.00423583 4.94638979e-04
37 TUBA4A -0.515580819 6.23121840 5.43442428e-04
38 IFNGR1 0.456042224 7.22474188 5.44607604e-04
39 SERPING1 0.485297806 6.10433032 5.56654068e-04
40 ATXN7L3 -3.106931429 2.15934959 5.80464003e-04
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sunitinib + Domperidone (SUN+DOM)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: SUN+DOM.1.D12, SUN+DOM.1.E1, SUN+DOM.1.E2
Investigative Units: U-6, 4, 5, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-SUN+DOM.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPS9 0.963950932 9.68746469 5.24612314e-14
2 MT2A 0.735115295 9.12844028 2.77634893e-10
3 RPL18 0.833295309 8.56460472 4.52901877e-10
4 CCL11 0.697701343 6.63421735 1.91833627e-09
5 RBM3 0.716587438 7.81286795 1.28172990e-07
6 OGN -2.376904322 3.89503729 4.82076055e-07
7 NTM 0.634598066 6.11851610 4.14163136e-06
8 COL21A1 -1.309071479 4.96136120 4.18851947e-06
9 PGK1 0.414380607 9.93327927 1.69183082e-05
10 HBB -3.050510370 6.65478655 2.06827559e-05
11 ITGA8 -1.974336191 3.13082885 3.02334673e-05
12 PTPRR 1.397156715 2.65143131 4.14757853e-05
13 SH3BGR 0.434562341 8.72322573 5.30773660e-05
14 COL14A1 -0.639129924 7.19239456 6.34302856e-05
15 ANGPT1 -0.791123759 5.43430978 6.50036425e-05
16 VCAM1 -0.957488662 4.98028800 7.35577028e-05
17 RHEB 0.604618398 5.41367606 1.29936961e-04
18 S100A4 -0.548539843 9.65546199 1.38200707e-04
19 ENO1 0.350042335 10.92110964 1.47848662e-04
20 AMIGO2 0.608104065 5.13563189 1.66031936e-04
21 LDHA 0.362753347 11.28270263 1.75988508e-04
22 TPI1 0.324752230 10.60665907 1.84992814e-04
23 FKBP2 0.719280694 4.87696175 1.85070983e-04
24 C10orf10 0.529620104 6.54157745 2.87194817e-04
25 HTR2B -1.351560524 3.71121586 3.09940143e-04
26 PCOLCE -0.555737381 6.14634530 3.92588030e-04
27 RALA 0.446588491 6.82378440 5.90066967e-04
28 FAM195A 1.873919014 1.60717542 6.22862606e-04
29 AFAP1 0.519484355 5.66646621 6.54467650e-04
30 LGALS1 0.304162932 12.25764168 6.91350259e-04
31 SLN -0.734436231 5.42808804 7.33763084e-04
32 LUZP2 -2.489213473 2.25824491 7.82445606e-04
33 JMJD1C -0.464318475 7.10834671 8.12518088e-04
34 C12orf4 -0.903423845 4.14892666 8.98271282e-04
35 EFEMP1 -0.340450494 10.68806819 9.05810979e-04
36 AURKA 1.526958067 2.03892251 9.68931782e-04
37 FBLN1 -0.634801504 5.11488959 1.03208720e-03
38 RNF4 0.428399795 6.11652782 1.04922128e-03
39 PLAUR 0.437293552 6.19011129 1.08918969e-03
40 FABP4 -1.025180227 5.26486579 1.12847679e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sunitinib + Loperamide (SUN+LOP)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: SUN+LOP.1.F5, SUN+LOP.1.F6, SUN+LOP.1.G9
Investigative Units: U-7, 8, 4, 5, 6
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-SUN+LOP.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 VIM 0.778498731 11.24384093 1.82635014e-15
2 HBB 2.610363372 7.72956118 3.07678774e-08
3 FABP4 1.352865187 5.64600851 2.23515608e-07
4 HMGB2 0.634563737 7.60008821 4.05971043e-06
5 IRX3 3.031976805 1.54908112 5.09243426e-06
6 STK17B -0.711502288 6.91186367 2.68273129e-05
7 S100A4 -0.593530546 9.65915799 3.50248748e-05
8 MT2A 0.499285692 9.07154439 7.00803029e-05
9 NSA2 0.643425969 7.10965482 7.77905398e-05
10 RMND1 0.778564282 5.02403719 1.02103993e-04
11 CCL2 0.589221466 7.80450872 1.53507321e-04
12 NCL -0.468922181 8.69351257 1.69353015e-04
13 PRPF38B -1.057226467 4.92250234 1.72703625e-04
14 SYNM -0.949932882 5.02418424 1.92563890e-04
15 KDELR3 -0.572927784 6.78808715 2.01379681e-04
16 ACTB -0.417136948 10.51815628 2.19545377e-04
17 SH3PXD2A -0.517834833 7.37006154 2.20202807e-04
18 AMOTL1 -1.016720071 4.75360989 2.28838915e-04
19 MYH10 -0.424434178 9.65578100 2.42357496e-04
20 THBS1 -0.459711223 9.41474258 2.53492790e-04
21 PTRF -0.545992956 7.30059080 2.64967720e-04
22 RGS5 -0.628579304 5.97696501 3.19493902e-04
23 CDKN2B -0.592625462 6.10948908 3.21385247e-04
24 RRBP1 -0.597726849 7.27238965 3.29113064e-04
25 RPE -0.928901421 4.27754079 3.38216101e-04
26 OXTR -0.872471891 4.45437150 3.50930482e-04
27 LETMD1 0.599062603 5.84682464 3.73357980e-04
28 ACTA2 -0.363002981 12.21345976 3.87760743e-04
29 WWC3 -1.310973802 3.54215635 4.04826508e-04
30 LOC339524 2.744894446 1.31889041 4.27567738e-04
31 EXOG -1.844864124 3.29585696 4.86407893e-04
32 TTL -0.894765272 4.25233937 5.69501037e-04
33 LINC00938 1.973325699 1.86217510 5.95248923e-04
34 OMD -1.476743824 3.53604634 5.99788609e-04
35 ADAMTS1 -0.695066400 5.49898090 6.22200657e-04
36 CCL20 2.275169520 1.62832146 6.25295379e-04
37 LBH 0.538451221 7.43601187 6.29059349e-04
38 MEIS1 -0.892316051 4.38328522 6.37104723e-04
39 ITCH -0.888531493 5.24966616 6.84585163e-04
40 H19 -0.759740286 5.30593987 6.88293792e-04
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sunitinib + Paroxetine (SUN+PAR)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: SUN+PAR.1.H2, SUN+PAR.1.H3, SUN+PAR.2.D4
Investigative Units: U-8, 10, 4, 5, 6, 7
Sequencing Runs: SR-1,2
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-SUN+PAR.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL18 1.792044297 8.92444715 1.56880431e-21
2 RPS15 0.971520144 10.06295483 2.13439464e-12
3 TRIB3 1.151354568 4.72856213 2.04508889e-09
4 GOT1 0.813606661 6.28239113 8.63843842e-08
5 MEG3 0.825083524 7.43104212 3.53826624e-07
6 MMP1 1.625354179 3.67032011 5.09007927e-07
7 S100A4 -0.769943204 9.64040820 2.35402112e-06
8 TUBA4A -0.852819530 6.20724594 2.76831312e-06
9 SLFN5 0.767903537 5.25768978 2.78515146e-06
10 ARRDC3 0.766442802 5.65689164 4.54921938e-06
11 SFPQ -0.888590839 5.29051577 4.55693835e-06
12 MT2A 0.589915755 9.10201315 5.63556886e-06
13 KIF23 -3.625681930 2.48299115 7.38257423e-06
14 ACTG1 -0.597319304 11.74873113 7.75240672e-06
15 ACTN1 -0.575936976 7.46699738 1.00088500e-05
16 GNG4 1.020886585 4.02024228 1.81034275e-05
17 GPR1 0.572603718 6.75254853 2.02336394e-05
18 MPHOSPH10 -0.620837082 6.41629672 2.28269797e-05
19 LOC256880 2.187337883 1.86284464 2.30572626e-05
20 TAGLN -0.557649100 11.15573314 2.32387239e-05
21 MTHFD2 0.541880323 8.78296466 2.33464106e-05
22 PRR13 0.585474643 6.57770879 2.49997504e-05
23 COL12A1 -0.634231349 7.78717656 2.52555497e-05
24 MAGED1 -0.573253695 7.07221030 4.11638917e-05
25 PDE4C 0.984430128 4.12991635 4.43598255e-05
26 MAB21L3 1.007725242 3.99203237 4.62605334e-05
27 SHISA9 1.455062098 2.70991010 4.78182650e-05
28 NEK8 1.307432664 2.91287944 5.24816084e-05
29 SYNM -0.939817054 4.99635083 6.44942464e-05
30 STK38 -0.999491668 4.68948369 6.51001209e-05
31 RNF125 1.321972302 3.09374402 6.64096660e-05
32 SKP1P2 1.382320710 2.95358427 6.95627180e-05
33 EDEM3 -0.956966117 4.66954240 7.05737740e-05
34 LOC100190986 0.840756830 4.54056559 7.68798032e-05
35 VCL -0.501785081 7.12181720 8.35838906e-05
36 DDX39A -0.969012868 4.66774819 8.73815180e-05
37 GSDMA 1.569342709 2.36484456 8.75958458e-05
38 ZNF566 0.849105986 4.17026797 8.79895902e-05
39 CBX6 -0.726567931 6.05868866 9.00488213e-05
40 PRELID2 0.896787684 3.93245934 9.97717202e-05
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sunitinib + Ursodeoxycholic acid (SUN+URS)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: SUN+URS.1.D9, SUN+URS.1.D10, SUN+URS.1.D11
Investigative Units: U-6, 4, 5, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-SUN+URS.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 VIM 0.825485363 11.24622640 2.18006574e-20
2 RPL28 0.733427640 10.45616816 7.02689353e-13
3 S100A4 -0.772053197 9.62127904 8.28510971e-08
4 COL21A1 -1.474498155 4.93437836 1.74965457e-07
5 RAB31 0.551852570 7.09540378 3.42000979e-07
6 MT2A 0.586671088 9.08291420 6.74223116e-07
7 BEND5 2.771274477 1.47985444 1.11612561e-06
8 ACTN4 0.644487578 5.80924810 7.16123391e-06
9 COL14A1 -0.687377166 7.17866513 8.74132525e-06
10 TAGLN 0.371664131 11.30372858 1.19418350e-05
11 SH3BGR 0.440965633 8.71867063 3.40862254e-05
12 GREM1 -0.697828053 5.85538473 3.72953316e-05
13 ZNF449 1.288875060 2.79549915 4.55212269e-05
14 RBM3 0.552794316 7.76496731 4.73776385e-05
15 FGF7 -0.440433433 8.98406873 5.58337838e-05
16 TIMP3 -0.460033823 9.75423569 5.82617534e-05
17 BMP6 0.898142798 3.73792374 7.89800253e-05
18 C10orf10 0.564318250 6.54553521 8.98766859e-05
19 VCAM1 -0.861642142 4.97524276 1.10595103e-04
20 HBB -2.524098052 6.67074113 1.15186372e-04
21 OMD -1.502187299 3.44261353 1.40784477e-04
22 PTK7 1.051444842 3.60487338 1.71212175e-04
23 HDX 1.596894173 1.97572066 2.10933804e-04
24 ACADSB 1.129650325 2.87548320 2.21955210e-04
25 DTD1 0.629736623 4.92360077 2.33078635e-04
26 EEF2 0.365749354 8.21255890 2.51241842e-04
27 FOXP1 -0.574636409 6.19742709 3.13773208e-04
28 NPR3 -0.463283034 7.43992323 3.36258875e-04
29 ANTXR2 0.524258290 6.14711684 3.53137006e-04
30 H19 -0.654387720 5.27608887 4.64492018e-04
31 PRSS23 -0.403881388 8.26742773 4.77265355e-04
32 CCPG1 0.393980039 7.29867097 4.98862032e-04
33 LOC645638 -0.507875884 6.30949225 5.36967285e-04
34 SLC25A36 0.524853187 5.31742520 5.45531449e-04
35 PFKFB4 1.232751348 2.63481602 5.58662764e-04
36 PTX3 -0.585525429 6.66541334 5.74802453e-04
37 TMEM150A -2.025794472 2.62092912 5.78114840e-04
38 SOD2 0.500380542 5.69008816 6.75264926e-04
39 TNRC6A 0.615489617 4.52346134 6.84240493e-04
40 HECW2 -0.941292123 4.31014153 6.84835323e-04
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Trastuzumab (TRS)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: TRS.1.A1, TRS.1.A11, TRS.1.C6, TRS.1.H11, TRS.1.H12
Investigative Units: U-2, 4, 5, 6, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-TRS.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RGS5 0.943013735 6.37944246 1.69856381e-16
2 TRIB3 0.875401770 4.72999335 1.77456339e-06
3 FABP4 -1.255730504 5.18046303 2.43272424e-06
4 GADD45B 0.925412719 4.07592281 2.59635249e-06
5 SREBF1 1.839726620 1.88853815 1.50257966e-05
6 SLN 0.655985777 5.75072656 1.92770488e-05
7 PTX3 0.617559860 6.97246511 2.27663918e-05
8 BRPF1 -2.269354077 2.50207834 3.75403933e-05
9 ACTA2 0.343495128 12.38365732 7.56887646e-05
10 ERV3-1 -0.938213781 4.25426645 8.43977091e-05
11 KLF6 0.568185030 5.28619175 1.03281848e-04
12 C6orf211 0.603885314 5.03921057 1.06275206e-04
13 OMD 1.001393299 3.93268812 1.96156005e-04
14 NPL 1.658313956 1.94238503 1.98002057e-04
15 PPRC1 -1.245534569 3.31895981 2.33893594e-04
16 ASPN 0.458448122 7.36336685 2.36877933e-04
17 LOC646762 -1.096936120 3.59720349 2.60251721e-04
18 MBTPS2 -0.819750218 4.03801172 2.65715288e-04
19 MDK 0.849302112 3.45902314 3.23082692e-04
20 DHRS3 -0.589092171 6.70069552 3.69608246e-04
21 MAP1B 0.287604069 8.60992285 4.31788447e-04
22 HERPUD1 0.388267355 6.63214200 4.46358674e-04
23 TNFAIP6 0.438704018 7.67595763 4.95468222e-04
24 MAZ 0.733459885 3.72055985 5.14426830e-04
25 ADAM21 -2.956925598 1.74683500 5.38025838e-04
26 LOC100134229 1.750878111 1.73846459 6.03907936e-04
27 RGS4 0.398861431 6.30765609 6.15884098e-04
28 INHBA 0.332228539 7.82629504 6.21275894e-04
29 HILPDA -0.474498990 6.13084174 6.37906171e-04
30 DIO2 1.343320286 2.18571191 6.50067736e-04
31 AJUBA 0.657826972 4.02523686 6.59029247e-04
32 NDC80 1.650371384 1.76238740 7.17444577e-04
33 SDPR 0.310968383 8.21571507 7.67498939e-04
34 JDP2 0.780635231 3.61206289 7.78362311e-04
35 CLK1 -0.559786275 5.02343874 8.35592224e-04
36 FIBIN 0.570362234 4.67410197 9.17041953e-04
37 PPP1R14A 0.680946808 4.17092833 9.68356611e-04
38 SAA1 -1.837037534 2.80333257 9.82357938e-04
39 RBM5 0.483248680 5.01301058 1.06469170e-03
40 LOC643401 -0.762991100 4.42123061 1.07332401e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Trastuzumab + Domperidone (TRS+DOM)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: TRS+DOM.1.B9, TRS+DOM.1.B10, TRS+DOM.1.C8
Investigative Units: U-4, 5, 6, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-TRS+DOM.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 PDGFA 0.691905601 5.71995039 7.27496339e-07
2 HBB -3.242724889 6.64493427 1.92606882e-06
3 CSNK1G3 -1.040760249 4.02464942 1.41951741e-05
4 ADAM19 1.138496842 2.76241093 4.97786370e-05
5 MYOZ2 0.986442174 3.29873120 1.52076848e-04
6 CTDSP2 -0.554787923 5.72423362 2.50064953e-04
7 ZNF449 1.090053809 2.72435880 4.06739261e-04
8 ARFGEF2 -0.809942377 4.09707578 4.06921052e-04
9 TNFAIP3 -1.862147288 2.37686992 4.46298917e-04
10 PRDM6 2.125500892 1.00807331 5.48295120e-04
11 CA3 0.649363720 4.39483166 5.69155541e-04
12 RALGAPA2 -1.339973394 1.84982789 8.45578793e-04
13 OPA1 -0.650591529 4.14339154 8.84717581e-04
14 GATS -1.866861035 2.01498657 9.90414910e-04
15 MYH11 0.757175819 3.58849182 1.02665670e-03
16 ANP32E 0.407550430 6.76936420 1.12302897e-03
17 OIP5-AS1 0.605725676 4.12244471 1.19257146e-03
18 LRR1 0.645421218 3.91540394 1.22013881e-03
19 PELI1 -1.794172918 2.38275438 1.23164085e-03
20 ZXDC -0.611427194 4.70123809 1.24911898e-03
21 WBP4 0.453231317 5.59084509 1.29693167e-03
22 VEPH1 0.367642913 7.48905814 1.51664024e-03
23 C7orf10 0.432845465 6.13615569 1.67511497e-03
24 ZRSR2 0.734692052 3.59991732 1.73552125e-03
25 CMSS1 0.448420150 5.71297363 1.91191967e-03
26 MB21D1 1.308878892 1.69027508 2.01898828e-03
27 CLPTM1 0.994356902 2.01737888 2.07845873e-03
28 ZNF146 0.379038112 6.65929090 2.13572824e-03
29 CDKN3 0.868018201 2.92778630 2.44624486e-03
30 SAA1 -2.121989120 2.70663679 2.55088478e-03
31 CCL11 0.350510550 6.55490609 2.70354260e-03
32 TGM2 -1.213285682 2.34568882 2.72023426e-03
33 IRS1 -1.251946115 2.10451699 2.85223250e-03
34 LRP11 -1.026788037 3.29689853 2.97062549e-03
35 SMARCA1 0.383650919 5.66405648 2.99717798e-03
36 SLC36A1 -0.733017050 2.90113659 3.01799049e-03
37 GEM 0.366046870 7.42585321 3.15406857e-03
38 TSHZ1 -1.239182741 2.33978903 3.16849208e-03
39 MLX 0.471009625 5.07163950 3.18954605e-03
40 TEX261 -0.714697188 4.23217235 3.24554684e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Trastuzumab + Loperamide (TRS+LOP)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: TRS+LOP.1.B4, TRS+LOP.1.B5, TRS+LOP.1.B6
Investigative Units: U-4, 5, 6, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-TRS+LOP.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 LEP 0.626247246 5.39409421 3.01816648e-05
2 FAM135A 1.593795732 1.91983322 3.52339365e-04
3 ZNF449 1.167797290 2.77915696 4.15169851e-04
4 DCTN2 -0.764016890 4.59117985 4.96048689e-04
5 SLC20A1 0.465841124 6.12103281 5.30645989e-04
6 CHORDC1 0.676868268 4.48478481 5.98661521e-04
7 CCL2 -0.537692910 7.60156188 7.34344705e-04
8 LGR4 0.634726590 4.84521267 7.44511260e-04
9 JAG1 0.556908936 4.93218947 8.02506618e-04
10 ANKRD27 1.179126514 2.57432242 8.61013837e-04
11 BDH2 -0.535822731 5.94361800 9.49135291e-04
12 MAP3K6 1.983172852 1.61365705 1.07097375e-03
13 LANCL2 0.677546862 4.31142874 1.08690138e-03
14 LINC00672 -1.872098037 2.56265125 1.12244295e-03
15 CDC34 1.330374247 2.11001094 1.58682942e-03
16 LTA4H -0.406205764 7.04020701 1.60255252e-03
17 DUSP10 0.759754864 3.73475216 1.70442074e-03
18 UBAC1 -1.285382202 3.07926013 1.71952750e-03
19 C9orf69 1.221952849 2.36664332 1.77296013e-03
20 F5 1.436563891 1.87994652 1.79709408e-03
21 AHCY -0.436566872 6.16738755 1.81366769e-03
22 MMP1 -1.438482671 3.09556670 1.83263089e-03
23 PRUNE2 0.745960697 3.64702461 1.89694682e-03
24 PPP4R1 0.643761789 4.14583273 2.00544126e-03
25 PDHA1 -0.463961921 5.84936312 2.14411187e-03
26 PRR26 2.063101207 1.32594723 2.41163812e-03
27 MDK 0.821482998 3.38156872 2.57832988e-03
28 PPP2R5E 0.746979188 3.51984426 2.59772582e-03
29 DDIT3 0.570797620 7.78451412 2.70039226e-03
30 ALDH2 -0.684265680 4.53151157 2.84026248e-03
31 MYLK 0.432630041 5.51949625 2.84985453e-03
32 LINC00574 -1.763802203 2.48108443 2.85415652e-03
33 NDRG3 -0.597681489 4.85713190 2.90134653e-03
34 TM4SF1 -0.383253208 7.44866447 2.92993424e-03
35 FAM173A 1.868959929 1.48890077 3.07487553e-03
36 TRIM33 0.828183356 3.50347630 3.33543701e-03
37 IDH3G -0.539974514 5.05707356 3.42410293e-03
38 AASS -1.054753622 3.38150904 3.48551278e-03
39 PDE6D -1.170032956 2.99357274 3.56486885e-03
40 RGS4 0.379355106 6.26246684 3.57956424e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Trastuzumab + Ursodeoxycholic acid (TRS+URS)
Control Samples: CTRL.1.A8, CTRL.1.A10, CTRL.1.B11, CTRL.1.B12, CTRL.1.C1, CTRL.1.C9, CTRL.1.C10, CTRL.1.C11, CTRL.1.E3, CTRL.1.E4, CTRL.1.F11, CTRL.1.H9, CTRL.1.H10
Drug Samples: TRS+URS.1.A3, TRS+URS.1.A7, TRS+URS.1.B1
Investigative Units: U-2, 3, 4, 5, 6, 7, 8
Sequencing Runs: SR-1
Normalized Counts: /Data/Human.A-48hrs-ReadCounts-0.1-Norm-CTRL-TRS+URS.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 HMCN1 1.104974769 6.00033479 1.27693975e-14
2 MYH11 1.702400430 3.95797784 9.60148899e-13
3 COL4A1 0.812595696 8.61235982 2.96199548e-12
4 MACF1 0.810360273 7.29651010 2.79559288e-10
5 CCL2 -1.193632499 7.56962234 4.98978750e-10
6 FAM162A -0.804365940 8.52590101 3.84459591e-09
7 LOC645638 -1.008729803 6.30867567 4.43280940e-09
8 SAT1 -0.777908477 7.90928237 6.49961944e-09
9 PGK1 -0.728851258 9.78655993 2.62046863e-08
10 SEC61G -0.676207207 10.12386938 2.79759208e-08
11 MMP16 1.382458172 3.80696389 3.58160529e-08
12 CCL11 -0.814230451 6.40788590 4.38112719e-08
13 HSPB11 -0.932645469 5.98141066 5.28466212e-08
14 SH3BGRL3 -0.637522936 9.52730892 6.23945653e-08
15 TMSB10 -0.628157265 12.66612878 8.23438539e-08
16 DMD 0.866207410 5.24051008 8.52741339e-08
17 NME1 -0.667244661 7.67124681 1.13750298e-07
18 SLC7A11 0.982791371 5.16130210 1.35304858e-07
19 NPC2 -0.696956897 9.55182227 1.52764777e-07
20 FAM229B -0.758077427 6.98272437 1.74899025e-07
21 AKT3 0.889172090 5.31883740 1.88177661e-07
22 SESN2 1.226793037 4.02125950 1.97047164e-07
23 SEMA5A 0.710139351 6.11016049 2.26729708e-07
24 P4HA2 -0.655858533 9.19289081 2.37090878e-07
25 HNMT -0.811658935 6.64956443 2.41491420e-07
26 DST 0.606935181 7.73063285 2.43388115e-07
27 DLC1 0.816730062 5.74797705 2.81228668e-07
28 CTGF 0.565503838 9.81826178 3.17374315e-07
29 ARL1 -0.651040100 7.71247236 3.30888694e-07
30 PELO -0.759220188 6.43612376 3.51200756e-07
31 MIR143HG 0.908699430 5.17373819 3.54887506e-07
32 POSTN 0.984087166 6.14722878 3.56906975e-07
33 EDNRA 1.509181708 2.96285139 3.57565229e-07
34 BACE1 0.893622386 4.93831426 3.92190845e-07
35 IL32 -1.519251124 4.48456776 3.95123255e-07
36 GALNT10 0.801116578 5.52279755 4.46340106e-07
37 ANXA1 -0.599907146 10.51361245 4.52786141e-07
38 MRPL14 -0.751621709 6.56531241 4.63244292e-07
39 TIMP1 -0.614709039 12.64634098 4.69823015e-07
40 FAM129A 0.603434415 7.08907908 4.92708775e-07
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Amiodarone (AMI)
Control Samples: CTRL.2.E12, CTRL.2.F1, CTRL.2.H3
Drug Samples: AMI.2.F4, AMI.2.F5, AMI.2.H5
Investigative Units: U-12, 17
Sequencing Runs: SR-2
Normalized Counts: /Data/Human.B-48hrs-ReadCounts-0.1-Norm-CTRL-AMI.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 NSA2 1.100254901 7.71462695 3.14896500e-09
2 PTK7 -2.257062736 4.25304773 4.45655555e-06
3 ST3GAL2 -1.921524282 4.50305837 5.71974408e-06
4 MLF1 1.442652605 4.62119924 4.85734291e-05
5 JUND 0.885307297 6.22135377 6.78037739e-05
6 GNG12 0.777989066 8.06693124 1.68234641e-04
7 BTBD7 1.234629140 5.00445159 1.97913190e-04
8 RPL18 -1.024970722 9.34092795 2.78284368e-04
9 LINC00968 1.156075960 4.99108121 3.27764147e-04
10 NUMA1 0.840317538 6.04653835 4.32182984e-04
11 RPS26 0.511464290 9.86660767 8.54019794e-04
12 PRUNE 1.619296405 3.74698718 9.23920058e-04
13 WDR45B -0.963150641 5.30117924 9.87425467e-04
14 CBX6 -0.716379729 6.07534576 1.32446187e-03
15 L3MBTL3 -2.464097240 3.11102697 1.38703775e-03
16 FCGRT -0.563046169 6.95020462 1.61380834e-03
17 BAHD1 -2.514457106 3.15589453 1.64965128e-03
18 TINAGL1 -0.653788191 6.25588116 2.06401055e-03
19 RNA45S5 -0.717416429 5.70151454 2.10176052e-03
20 ZNF528 1.158958167 4.47070516 2.20105886e-03
21 TRIM6 4.867341968 2.45940486 2.28763862e-03
22 TMEM54 -2.736989634 2.93318557 2.46600314e-03
23 ACBD6 1.040840148 4.92497614 2.46797333e-03
24 MBNL1-AS1 -1.863907583 3.23078164 2.51450847e-03
25 RRP7A -0.958203084 4.87322850 2.69501956e-03
26 CD81 -0.603358725 6.20762959 2.84225935e-03
27 TMEM130 -1.091032059 4.68633206 2.96896057e-03
28 PSME4 -1.095492894 4.51276429 3.00964636e-03
29 MYD88 -1.447679892 3.90792073 3.06060476e-03
30 PPP2R2D -1.134220316 4.72620252 3.08308458e-03
31 GTPBP4 -0.566989224 6.38150528 3.33576613e-03
32 SAV1 -1.353851033 3.93848672 4.04859474e-03
33 TOMM20 0.600876554 6.13152271 4.14642113e-03
34 GPR180 -1.088699312 4.52798619 4.40804502e-03
35 IL13RA1 -1.083879110 4.52190923 4.49824140e-03
36 TAOK3 0.814129937 5.27799946 4.52975334e-03
37 AFF3 -1.185405924 4.15629261 4.56660875e-03
38 BLVRB -0.962608044 4.93868927 4.67261102e-03
39 DNAH14 4.566425499 2.32622994 4.68253864e-03
40 TRUB2 -1.696806439 3.47834876 4.94432837e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Flecainide (FLE)
Control Samples: CTRL.2.E12, CTRL.2.F1, CTRL.2.H3
Drug Samples: FLE.2.F6, FLE.2.F7, FLE.2.H6
Investigative Units: U-12, 17
Sequencing Runs: SR-2
Normalized Counts: /Data/Human.B-48hrs-ReadCounts-0.1-Norm-CTRL-FLE.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL18 -1.415680813 9.23693839 7.33880600e-21
2 FAU -0.632849550 8.51678434 9.96120064e-05
3 HAPLN1 1.198887430 4.95825965 2.76148024e-04
4 TMEM167B -0.964815538 5.99690228 3.28935127e-04
5 KRT18 0.779644191 6.65060025 3.84962508e-04
6 SLC40A1 -0.559630845 8.01802382 4.63939070e-04
7 NOC3L 0.967706660 5.53966588 5.55923693e-04
8 RASA4 -2.228569342 3.64221087 7.06920853e-04
9 CSTF1 1.028607363 5.38896903 7.12453036e-04
10 ST3GAL2 -1.506220991 4.69124192 1.14301149e-03
11 LOC400548 -1.751148794 3.91392356 1.17351392e-03
12 TNFRSF12A -1.010376846 5.19777799 1.59432995e-03
13 CLN3 -2.008601317 3.74751448 1.89831179e-03
14 TSLP -1.013775270 5.44297377 1.92248327e-03
15 PLIN2 0.706757224 6.50273246 1.92784013e-03
16 GFOD2 -0.963668423 5.02486470 2.30462898e-03
17 CDKN1B -1.041653123 4.43497963 2.32175922e-03
18 ANKRD27 -2.611975598 3.24643868 2.35751008e-03
19 KIAA0586 -1.811955993 3.97062814 2.35810652e-03
20 DDX21 0.657151650 6.64575776 2.49580303e-03
21 SQRDL -1.230571863 4.17132899 2.70836915e-03
22 MOB4 -1.417141203 4.41477121 2.90505916e-03
23 SLC7A14 -2.025222753 3.51583274 2.94247324e-03
24 ALCAM -0.657159485 6.24882308 3.05922320e-03
25 MLF1IP 2.702463981 2.81532076 3.06058619e-03
26 ANKRD62 -3.119146395 3.02650876 3.07255959e-03
27 INPP5B -1.470597901 4.25235810 3.09459912e-03
28 MN1 1.452129824 4.21081000 3.16573955e-03
29 FRY -0.894797121 5.27236459 3.18798466e-03
30 RBMS3 -0.542818561 6.95478193 3.28504633e-03
31 RNF146 -1.001513362 5.09511864 3.34624826e-03
32 ZDHHC3 -1.005834230 5.02237452 3.38888780e-03
33 ACLY 0.954872376 5.26445830 3.54609861e-03
34 IDH2 1.620384173 3.73479478 4.21991717e-03
35 CTSZ -1.357943505 4.04809155 4.40019652e-03
36 LOC100144595 -1.798730931 3.36700239 4.47529182e-03
37 STC1 1.346450048 4.15110689 4.50138255e-03
38 GGNBP2 -0.747039889 5.81475911 4.68654292e-03
39 ECSIT 2.422985840 3.20192078 4.69344066e-03
40 GPR78 -1.923656286 3.45631604 4.74650270e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Milrinone (MIL)
Control Samples: CTRL.2.E12, CTRL.2.F1, CTRL.2.H3
Drug Samples: MIL.2.F2, MIL.2.F3, MIL.2.H4
Investigative Units: U-12, 17
Sequencing Runs: SR-2
Normalized Counts: /Data/Human.B-48hrs-ReadCounts-0.1-Norm-CTRL-MIL.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 IFITM1 0.993457259 7.58146598 1.27634980e-07
2 NUMA1 1.259472386 6.32798768 2.28054332e-07
3 ACAN -2.596666412 4.45292221 3.32764919e-06
4 ACTA2 -0.742614693 13.33562300 5.76520371e-06
5 PPAP2B 0.953102064 6.71676603 5.77983354e-06
6 MYH11 -0.784986184 7.92929416 8.30599107e-06
7 PTK7 -2.496237942 4.36960006 1.16153840e-05
8 IGFBP4 0.795777855 7.66203288 2.07029525e-05
9 IGFBP5 0.669216078 9.11862807 6.23122440e-05
10 TUBA1B -0.636009895 9.46253185 1.06095052e-04
11 MAP3K7CL -0.651033934 9.06907686 1.15050414e-04
12 RHOBTB3 0.696060715 7.50136414 1.32323180e-04
13 LUM 0.618769366 9.14247284 1.58710031e-04
14 PKD2 -0.807782169 6.62797527 1.79495325e-04
15 METTL7A 1.091250219 5.42285919 2.34068927e-04
16 LOXL1-AS1 -3.410713621 3.29179846 2.79581422e-04
17 ST3GAL2 -1.631912585 4.68117072 3.01495699e-04
18 ABCA8 0.969187624 5.79867495 3.23147300e-04
19 DCN 0.572323576 10.86802464 3.55054682e-04
20 ANKRD1 -0.834462793 6.24303184 3.98220497e-04
21 TSPAN2 -1.721952262 4.40230524 4.48402695e-04
22 SERPINE1 -0.565777347 9.89532824 5.02020300e-04
23 MYL12A -0.563749866 11.11591515 5.09152660e-04
24 LHFP 0.666290122 7.14412485 5.19567229e-04
25 TINAGL1 -0.837887527 6.25244124 6.04756588e-04
26 THRB 3.126734227 3.03149823 6.75740252e-04
27 COL3A1 0.542510146 11.32943301 6.85322086e-04
28 LAMP1 0.829055554 6.19281552 7.02202949e-04
29 FAM13C 0.868312799 5.99106021 7.86277520e-04
30 NKIRAS1 1.328539584 4.61278336 8.23623226e-04
31 SHC3 1.589131825 4.46759152 8.57314340e-04
32 HAX1 -0.636919321 7.13411790 9.83551098e-04
33 TUBB -0.532310409 9.61868343 1.06301872e-03
34 ADAMTS7 -2.423035226 3.60273523 1.08057391e-03
35 RARRES3 1.445025750 4.36943952 1.09599009e-03
36 SEMA5A -0.744423883 6.24637750 1.21953763e-03
37 PDIA3 -0.804413682 6.22379974 1.37892224e-03
38 LOC100270804 3.450502172 2.77578398 1.61901319e-03
39 PTX3 -0.636167857 7.01169357 1.64988663e-03
40 DDX27 0.941148936 5.36940916 1.70969546e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Flecainide (FLE)
Control Samples: CTRL.2.A1, CTRL.2.A2, CTRL.2.G9
Drug Samples: FLE.2.A7, FLE.2.A8, FLE.2.G11
Investigative Units: U-9, 13
Sequencing Runs: SR-2
Normalized Counts: /Data/Human.D-48hrs-ReadCounts-0.1-Norm-CTRL-FLE.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 TRIB3 1.128607541 5.401314328 3.05605134e-09
2 AAGAB -0.873933099 5.197612109 2.26796066e-06
3 SLC7A5 1.475108603 2.755482372 1.33649186e-05
4 PTX3 0.671541214 6.599160933 4.41150399e-05
5 LACE1 2.214370329 1.681205355 2.00459394e-04
6 FZD6 0.921880672 3.259627131 2.88874871e-04
7 VTN -2.842860836 0.936588354 5.47109999e-04
8 LURAP1L 0.740684277 4.692281992 6.18827725e-04
9 FER 0.747581970 4.372528306 7.86135492e-04
10 CDKN2AIP -1.442519006 2.345557671 7.89994400e-04
11 PPME1 0.608117525 5.373184865 8.69131740e-04
12 PTPN1 -0.785345479 3.731304551 8.82064236e-04
13 TNFAIP6 0.598955442 7.006288905 9.26192159e-04
14 SIPA1L1 0.888928491 3.635560526 1.20129647e-03
15 MTHFD2 0.506475935 8.469869041 1.40456312e-03
16 GDF15 0.700358039 4.531752309 1.50329128e-03
17 DZIP3 0.735879631 3.767881565 1.51334159e-03
18 XAF1 0.619149428 5.447893204 1.53478164e-03
19 TMC5 -1.115883466 2.615636470 1.54135931e-03
20 ATOH8 1.433144847 2.172579506 1.55921068e-03
21 RIPK2 1.006207534 2.960336730 1.72445973e-03
22 RFX7 1.536473347 2.422969378 1.82678965e-03
23 JMJD1C 0.438687843 6.825562750 1.91739196e-03
24 SKAP2 0.672334069 3.914643739 1.92696115e-03
25 CCDC148 1.922347783 1.529173389 2.11492967e-03
26 CDK11B 0.932033835 2.676936431 2.42163304e-03
27 IL8 -2.275640984 0.966114383 2.61389122e-03
28 SLC40A1 -0.444648350 7.819633620 2.63982508e-03
29 TMEM109 -0.704071088 4.558620164 2.76521108e-03
30 SPRYD3 -0.632684814 4.286906770 2.80946881e-03
31 NACC2 -0.730767253 3.496991860 3.05823983e-03
32 FAM129B -1.026812403 2.806248830 3.16032370e-03
33 ZNF468 0.706822701 4.091637455 3.19939177e-03
34 BRF2 -1.257312095 2.167640544 3.24505694e-03
35 GFM1 0.769583804 3.350106204 3.25995912e-03
36 KLF10 0.568669595 4.739853020 3.30651732e-03
37 DEXI -0.840622574 3.284059212 3.72274196e-03
38 CTH 1.220431825 2.977443579 3.80626511e-03
39 SLC7A1 0.698511478 4.494452629 3.95421516e-03
40 ZNF331 -0.686595176 3.525569229 4.02516023e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Trastuzumab (TRS)
Control Samples: CTRL.2.A1, CTRL.2.A2, CTRL.2.G9
Drug Samples: TRS.2.A9, TRS.2.A10, TRS.2.G12
Investigative Units: U-9, 13
Sequencing Runs: SR-2
Normalized Counts: /Data/Human.D-48hrs-ReadCounts-0.1-Norm-CTRL-TRS.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 TRIB3 1.096521602 5.393571421 7.30158118e-09
2 TNFAIP6 0.666468276 7.056249243 1.29743589e-05
3 GFM1 1.028498987 3.510219213 7.32971945e-05
4 FOXS1 1.346807374 2.995992713 1.69693680e-04
5 MYL4 0.641785942 5.497491206 1.97439904e-04
6 PRAF2 -1.003238162 3.943356774 2.20154945e-04
7 NAP1L5 -3.683969769 1.099303174 2.42087404e-04
8 DEXI -1.169637628 3.198595514 2.85888790e-04
9 LURAP1L 0.827577374 4.749317697 2.98183855e-04
10 CCL11 0.678969616 6.063077440 3.20465299e-04
11 LACE1 2.051848993 1.602998459 3.23345122e-04
12 MTHFD2 0.568059410 8.507088599 3.27683700e-04
13 PINLYP 2.266904089 1.563918959 4.22636012e-04
14 CBX6 -0.790769129 5.827058040 4.81082939e-04
15 LACTB2 0.629550924 4.922485140 6.76947596e-04
16 CCL2 0.674751598 6.620233085 6.85502273e-04
17 HSD17B6 1.373967399 2.420256318 8.02007292e-04
18 SCD 0.742962486 5.567601648 9.90449658e-04
19 AQP4-AS1 -2.075886220 1.668305380 1.05297003e-03
20 FZD6 0.966716412 3.268808245 1.07634818e-03
21 CRIP1 0.739125618 4.470799942 1.28616417e-03
22 SLC4A5 0.749865895 4.441393715 1.30410008e-03
23 SMARCAL1 0.775423814 4.285230938 1.30694331e-03
24 MPP4 5.065569183 0.764124771 1.32202522e-03
25 KLF10 0.773068441 4.867561083 1.32233452e-03
26 PPME1 0.568268809 5.368417358 1.39121514e-03
27 NEDD4L -0.902113200 3.370089009 1.61177455e-03
28 NCBP2-AS2 1.251173083 2.704812353 1.68142179e-03
29 ISOC2 -0.923657700 3.497285725 1.86994329e-03
30 LOC283693 -1.036191273 3.095296353 1.91407009e-03
31 ATG16L1 -1.370105520 2.460293192 2.20226899e-03
32 RAB20 -2.678376302 1.033561478 2.22956666e-03
33 LOC730102 2.305181125 1.111339762 2.31969835e-03
34 RBM18 0.610784646 5.281785074 2.33134370e-03
35 CDKN2AIP -1.271134263 2.407276235 2.34919937e-03
36 C4orf19 -0.661264356 4.116362141 2.70726075e-03
37 LOC100129361 -0.591603757 4.803888462 2.78849107e-03
38 IER5 0.750874446 3.469919658 2.87190312e-03
39 CPSF4 0.797002753 3.803841980 2.95460157e-03
40 PRR16 0.795021658 3.627427289 3.17801614e-03
Release Date: June 30, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Trastuzumab + Ursodeoxycholic acid (TRS+URS)
Control Samples: CTRL.2.A1, CTRL.2.A2, CTRL.2.G9
Drug Samples: TRS+URS.2.B1, TRS+URS.2.B2, TRS+URS.2.H2
Investigative Units: U-9, 13
Sequencing Runs: SR-2
Normalized Counts: /Data/Human.D-48hrs-ReadCounts-0.1-Norm-CTRL-TRS+URS.txt
Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 MT1X -1.240863560 5.411278055 4.74348955e-08
2 DPM3 -1.137318242 4.143437150 1.06760697e-06
3 ANGPTL4 -1.152481640 5.075840570 2.54824498e-06
4 KLF10 0.905364530 4.987186578 3.06546031e-06
5 NDUFA4L2 -0.852446499 7.170939684 3.61353933e-06
6 TPI1 -0.711066532 10.031560848 4.47605595e-06
7 PGK1 -0.689482236 9.290535045 6.89339168e-06
8 TRIB3 1.135427895 5.431242451 8.57685140e-06
9 LDHA -0.661978280 10.767526863 1.73003435e-05
10 SESN2 1.448275710 3.616597137 2.79091544e-05
11 CTH 1.656951549 3.289008316 4.93161919e-05
12 MT2A -0.865656688 10.043911084 5.41732564e-05
13 FKBP2 -0.961051580 4.166865242 6.50571726e-05
14 BMP2K 2.824568990 1.434529025 7.12907726e-05
15 ATF3 1.712225494 2.592002706 7.86862929e-05
16 MT1E -1.002214864 5.188744114 1.26705863e-04
17 ADAM33 1.282370238 2.762687143 1.28142233e-04
18 PTX3 0.749333939 6.659808821 1.29427185e-04
19 CHST7 -1.393914678 2.962524570 1.65380399e-04
20 HILPDA -0.774373167 5.708672840 1.79108764e-04
21 ZNF468 0.794251801 4.196161681 2.29918962e-04
22 ENO1 -0.546264425 10.207947752 2.61435031e-04
23 CEBPG 0.741339445 4.898821739 3.19478428e-04
24 FZD6 0.999570893 3.326546219 3.44026225e-04
25 RASSF1 -1.262716469 3.032945577 3.54192420e-04
26 LURAP1L 0.783638500 4.757952595 4.30513449e-04
27 SLFN11 -0.669018410 4.597400484 5.66914587e-04
28 COBLL1 0.656114296 4.782028156 6.01118680e-04
29 DZIP3 0.776639515 3.847643365 6.62223154e-04
30 MED13L 0.735510645 4.624925011 7.08041198e-04
31 RFX7 1.422437971 2.462601528 8.05971306e-04
32 RIC8A -0.644878475 4.944923692 8.10746502e-04
33 SETD1A -3.127411580 1.223020868 8.76886569e-04
34 AAGAB -0.630913881 5.308914272 9.00843654e-04
35 PIN4 -0.564275850 5.845232279 9.52500008e-04
36 RIOK2 -0.573170618 5.321222163 1.20256753e-03
37 GFPT2 -3.046404002 1.156498717 1.30062006e-03
38 ITGA1 0.605430289 5.488095700 1.33420236e-03
39 FXYD1 3.398088217 0.932670874 1.33924780e-03
40 MRPL17 -0.540812616 7.037448124 1.35940808e-03
Release Date: June 30, 2015
Cell Lines: PromoCell Cardiomyocyte, Line A (LPC-1001);Line B (LPC-1002); Line D (LPC-1003)
Details: Diffrentially expressed genes for all experimental units within sequencing runs SR-1 and SR-2.
Investigative Units: U-2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17
Sequencing Runs: SR-1,2
Download: Level-3-R2015-06-30
Release Date: August 20, 2015
Cell Lines: PromoCell Cardiomyocyte, Line A (LPC-1001);Line B (LPC-1002); Line D (LPC-1003); Line E (LPC-1004)
Details: Raw FASTQ files for sequencing runs SR-3.
Investigative Units: U-8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
Sequencing Runs: SR-3
Download: Request Data
Release Date: August 20, 2015
Cell Lines: PromoCell Cardiomyocyte, Line A (LPC-1001);Line B (LPC-1002); Line D (LPC-1003) ; Line E (LPC-1004)
Details: Complete unique molecular identifier counts for sequencing runs SR-3.
Investigative Units: U-8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
Sequencing Runs: SR-3
Download: Raw-Data-R2015-08-20
Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Afatinib (AFA)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: AFA.3.F21, AFA.3.H24, AFA.3.K2
Investigative Units: U-20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.AFA.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 MARCKSL1 2.141589515 4.96135378 1.71668856e-14
2 RPS9 -0.935546966 9.91196258 1.06047309e-11
3 RPL18 -0.768174012 8.63664036 1.64326580e-07
4 BRI3 1.035884341 5.49477786 7.52050130e-06
5 MRPL54 -1.637086056 4.46878866 1.38846808e-05
6 CDR1 0.751738355 6.65884112 1.66119447e-05
7 HSDL2 -1.092356445 5.41106246 2.33259129e-05
8 PTK7 1.575917177 4.01343176 2.66811658e-05
9 ITSN1 0.898324217 5.70963846 3.36964441e-05
10 PCNX 1.405354040 4.10967371 1.06376930e-04
11 CYP2U1 1.781118805 3.45841652 1.35021306e-04
12 NAT1 -1.465674054 4.27158842 1.41841121e-04
13 RLIM 1.213112671 4.46584652 1.67392047e-04
14 MRPS28 -0.881704464 5.70707455 1.99941891e-04
15 RPF2 -0.682788622 6.60132619 2.86855513e-04
16 PEX6 2.663943737 2.49648139 3.28657885e-04
17 RPL28 -0.484229652 9.80920909 3.75938035e-04
18 MASP1 1.337085366 3.92980200 4.38072376e-04
19 ZRANB3 2.972974256 2.27011576 5.15105715e-04
20 PEX19 -0.643368452 6.60924578 5.75366816e-04
21 ATG5 -1.165274930 4.52259361 7.71407816e-04
22 ARMCX6 -0.705758402 6.09635592 8.93731197e-04
23 EVL 2.879845013 2.23250540 9.05294569e-04
24 TM7SF3 1.035101681 4.55127504 9.81447545e-04
25 BUD13 1.822145611 2.96354028 1.13644933e-03
26 ADAMTS1 0.846892941 5.06081168 1.36133832e-03
27 WHSC1 1.683606889 3.09940261 1.40858165e-03
28 S100A4 0.417544248 9.92668537 1.43110728e-03
29 LYPLAL1 -0.590617418 6.59628172 1.50401101e-03
30 STRN4 -1.003426385 4.75226469 1.57889425e-03
31 GZF1 -1.796702422 3.39436457 1.72518266e-03
32 TMED5 0.827705501 5.09209015 1.73035634e-03
33 TFIP11 -1.193473970 4.23436586 1.80321436e-03
34 PBXIP1 0.967058459 4.54329570 1.85411150e-03
35 TNFRSF21 1.448410922 3.45015290 1.90451234e-03
36 MPP5 1.386250746 3.57651357 1.95326427e-03
37 TGFB1I1 1.626840908 3.08317190 2.04748273e-03
38 EIF4H -0.722346519 5.71979746 2.08394683e-03
39 TMEM181 1.011171186 4.44076136 2.13780774e-03
40 EEF1E1 -0.535907050 6.96572640 2.17730543e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line E (LPC-1004)
Drug Treatment: Amiodarone (AMI)
Control Samples: CTRL.3.L4, CTRL.3.M4, CTRL.3.M5, CTRL.3.N18
Drug Samples: AMI.3.L5, AMI.3.L6, AMI.3.M6
Investigative Units: U-26, 27, 29
Sequencing Runs: SR-3
Normalized Counts: Human.E-Hour.48-Plate.3-ReadCounts-Norm-CTRL.AMI.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 DHRS3 -1.941783846 5.52265063 6.26811635e-11
2 NSA2 -0.920398812 8.08567532 3.27410246e-07
3 IGFBP5 0.761917800 8.27326898 6.32481286e-06
4 DIRAS2 5.628227765 2.57168324 1.41243132e-05
5 RPL22 0.648253160 11.60026319 1.52665860e-05
6 CDR1 -0.819687299 7.02366279 2.41800353e-05
7 RPS24 0.603066450 11.75652069 5.51820190e-05
8 SFRP4 -1.020118262 5.68009198 1.57342201e-04
9 BROX 1.344866593 4.76372002 2.28857059e-04
10 IFI27 -0.905213430 5.82797056 4.36271616e-04
11 TLE1 3.649889895 2.48975390 5.81534923e-04
12 ADH1B -0.564594534 9.18747183 5.85494911e-04
13 SIAH1 1.201816562 4.69260590 6.23083094e-04
14 TNS1 0.674564468 6.74093449 6.36291351e-04
15 FABP4 -1.226153616 4.71173474 6.50690068e-04
16 ISG15 -1.118278621 4.69951862 8.16398576e-04
17 FAM13C 0.746423794 6.26817611 8.17206043e-04
18 RARB -1.403473024 4.17397001 9.08947400e-04
19 NTRK2 0.853796565 5.43292910 9.55491504e-04
20 MCPH1 1.534718567 3.92889567 9.68809197e-04
21 POSTN -0.615885184 7.62945766 1.01085342e-03
22 DNAJC6 4.939908037 2.18530634 1.04183867e-03
23 ZNF75D 4.907111483 2.14734786 1.07064021e-03
24 CAMSAP1 3.471622093 2.38396371 1.10312312e-03
25 DKK3 0.806094400 6.01795849 1.19182147e-03
26 PLIN2 -0.636392031 7.30191279 1.25884400e-03
27 CENPN -1.251900729 4.31276570 1.49263502e-03
28 FGF7 -0.642125762 6.77051832 1.87812624e-03
29 PEX5 3.358376381 2.33353476 1.95063629e-03
30 PAN2 1.925493081 3.05124153 2.04082002e-03
31 VIT -1.638214697 3.61242847 2.38616880e-03
32 PKD2 0.803090890 5.52806085 2.43526360e-03
33 LNPEP 2.952184164 2.56340346 2.49820960e-03
34 DLGAP5 -4.998807213 2.13623643 2.89737450e-03
35 ZMYM4 1.055456951 4.50868920 2.97105973e-03
36 PTK7 0.977135346 4.55338828 3.00469624e-03
37 STK38L 0.574230346 6.96497657 3.14228776e-03
38 QKI 0.708169629 5.80653513 3.16658320e-03
39 COL8A1 0.534857894 7.41674010 3.24660064e-03
40 VEGFA 0.999937389 4.71978524 3.25454318e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Bosutinib (BOS)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: BOS.3.F15, BOS.3.H18, BOS.3.J20
Investigative Units: U-20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.BOS.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPS9 -1.139363545 9.85745052 1.88606207e-15
2 PTK7 2.332741766 4.50710036 3.46712240e-13
3 RPL18 -0.874632955 8.60156319 5.72283759e-09
4 ACTA2 0.660585546 13.18963831 3.66591891e-07
5 IGFBP5 1.002187096 5.70491957 2.81029603e-06
6 MYLK 0.912319256 5.75047664 1.52460490e-05
7 CLEC2B -0.704690970 7.54411445 1.67464638e-05
8 KRT18 0.625534670 8.12679764 2.06415615e-05
9 S100A4 0.567155076 9.98562300 2.46385571e-05
10 CCL2 -0.651149152 7.83832783 3.55557378e-05
11 TAGLN 0.530025595 9.97984014 8.23007315e-05
12 SCG2 -0.736444685 6.47023246 1.17964941e-04
13 KLHL2 -2.857123167 2.75427254 1.69966080e-04
14 FTH1 -0.520951643 9.86272636 1.92788487e-04
15 RHBDD3 3.247367776 2.12736209 2.47803247e-04
16 PAK1IP1 -0.817114989 5.82261140 2.53477685e-04
17 VWA5A -1.296205690 4.31086344 3.19356131e-04
18 RGS2 -1.006432096 5.02685359 3.93452370e-04
19 CA3 1.017913094 4.70706835 3.96631226e-04
20 PSG5 1.369860211 3.80957978 4.25646640e-04
21 LOC100505633 0.530378088 7.78042534 4.56596729e-04
22 LY96 -0.656802361 6.57935601 4.57553178e-04
23 DMTF1 0.944949431 4.85146685 4.63847876e-04
24 RGS5 0.555791878 7.26068065 5.43006375e-04
25 TPM2 0.484230952 8.83805987 5.87932720e-04
26 LOC645638 0.600956275 6.50031972 7.06978713e-04
27 NSA2 -0.564767870 7.24626150 8.42953574e-04
28 FAM63B 1.075691436 4.39395025 9.38678209e-04
29 FHOD1 -5.051018834 2.14611835 9.60632320e-04
30 ARL4A 0.678076941 5.76868143 1.22855768e-03
31 TPD52L1 0.870125205 4.90503073 1.23798835e-03
32 SLC20A1 -0.683605124 5.94392894 1.35432745e-03
33 FTL -0.427984350 14.26330598 1.38593749e-03
34 ZNF354A 2.208803266 2.42154475 1.78484046e-03
35 ADAMTS6 1.383249905 3.50267157 1.88047810e-03
36 LTA4H -0.483793948 7.90136574 1.93696754e-03
37 CRIP2 0.632509590 5.85767552 2.17537539e-03
38 MFAP5 0.403227668 10.84147304 2.36918840e-03
39 SNTB2 0.914308524 4.55293957 2.49761927e-03
40 ACTR3 0.534915211 6.58738776 2.51977896e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Bosutinib (BOS)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: BOS.3.G19, BOS.3.I11, BOS.3.I12
Investigative Units: U-21, 23, 18, 12
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.BOS.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL18 -2.284426661 9.79899616 3.84070136e-40
2 RPLP2 -1.616402571 10.68430749 1.33591347e-22
3 RPS9 1.130920790 9.34077061 1.64267750e-12
4 RPLP1 -1.088441354 12.45193416 1.56191845e-11
5 MT2A -0.917777550 8.92189312 3.77395008e-08
6 HMGCS1 0.924904465 7.21316151 1.52444509e-07
7 TPR -0.824777744 8.33899102 9.36579470e-07
8 OGN 0.747878076 7.33788762 9.99074817e-06
9 SPIRE1 -0.845212603 6.53137353 3.69415519e-05
10 TP53I3 2.128871769 2.70978507 5.21439091e-05
11 ITGBL1 0.748554979 6.38058912 5.52961262e-05
12 RPS24 -0.639878855 11.49580459 5.74308878e-05
13 AGFG1 1.130835363 4.39123798 1.02121163e-04
14 ZSWIM7 -1.212226500 4.22817384 1.34994636e-04
15 OMD 0.691207342 6.88565182 1.43231053e-04
16 FLRT2 2.402992422 2.10228677 1.53604252e-04
17 CLTA 0.871137470 5.47286210 1.76704822e-04
18 GPX3 -1.221340085 4.29069903 1.83103415e-04
19 ANTXR1 0.673653544 6.85716473 1.85484296e-04
20 DHCR24 1.248120123 4.01202819 2.06050733e-04
21 LRSAM1 -1.069150745 4.81892290 2.35208995e-04
22 EYA4 1.385524160 3.62165590 2.41525427e-04
23 GJA1 0.656192870 6.99063027 2.69172585e-04
24 TAB2 1.045660186 4.39631897 2.70287527e-04
25 PRKAA2 1.477630134 3.44683945 2.82582825e-04
26 TNFRSF11B -0.581936039 10.05417722 2.86617097e-04
27 TMEM97 1.047624543 4.51845139 2.95129478e-04
28 FDPS 0.622431674 7.25829116 3.39345804e-04
29 NEGR1 0.782664408 5.69000193 3.48476106e-04
30 NOL7 -0.583265222 8.70191767 3.77051433e-04
31 LOC100505633 0.585646569 7.47761270 4.08666499e-04
32 HTR2B -0.604948564 7.88225517 4.17662521e-04
33 ZHX1 -1.131359888 4.34824943 4.28770722e-04
34 FMNL2 1.026535620 3.80768231 5.86131161e-04
35 YWHAH 0.762822655 5.64980009 6.40270780e-04
36 RPL6 -0.540613719 12.59141750 6.68570468e-04
37 TMEM181 0.981416820 4.33977469 6.91940939e-04
38 GALNT1 0.718851637 5.87848183 7.10507130e-04
39 SCG2 -0.555502765 8.58338243 7.16837533e-04
40 ST3GAL2 1.572517724 3.24791201 8.09533139e-04

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Cefuroxime (CEF)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: CEF.3.F12, CEF.3.H11, CEF.3.J12
Investigative Units: U-20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.CEF.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 NQO1 2.792682167 7.13728466 6.76866690e-65
2 AKR1C3 1.860564058 8.39530501 4.51638972e-43
3 AKR1C1 2.947321930 5.30570268 3.01168827e-30
4 AKR1B10 3.650820625 4.71180470 2.74829422e-28
5 TXN 1.293984872 11.70915550 2.78749295e-28
6 PTGR1 1.611144290 7.52737731 1.01580747e-27
7 TXNRD1 1.250488817 9.43157474 1.57180993e-23
8 SLC7A11 2.197782717 5.54469561 8.84610506e-22
9 AKR1C2 2.865752533 4.77256198 1.97974979e-21
10 HMOX1 3.413434260 4.39130091 4.15784072e-21
11 RPS9 -1.238793885 9.84190152 5.67587690e-21
12 FTL 1.016983549 14.88307336 7.86718824e-19
13 CDK5RAP2 1.644702342 6.13376050 7.21974286e-18
14 TNFRSF11B -1.143416576 9.16324943 3.47599903e-17
15 MGST1 1.037384092 9.77929639 3.78849316e-17
16 FTH1 0.961139547 10.47977518 1.46102468e-15
17 RPL18 -1.027697508 8.56953314 3.55153793e-13
18 ASPH 1.494557162 5.75837640 9.92434464e-13
19 AFP 4.006315503 3.36148982 2.12175387e-12
20 PIR 1.739880257 5.17667467 2.57828921e-12
21 RPL28 -0.912414988 9.68967034 2.80555822e-12
22 TKT 1.619196571 5.35488571 6.75409297e-12
23 GSTM3 0.966507994 7.58541420 3.22624742e-11
24 CFHR1 2.974554776 3.47311405 5.65847189e-10
25 ANKRD1 -1.247766180 6.30624072 8.51598489e-10
26 TALDO1 1.019386967 6.71278068 8.70204546e-10
27 AKR1B1 1.243849611 5.86067589 1.04955401e-09
28 IGF1 -0.848498789 8.42320589 1.89201910e-09
29 PGD 1.303710170 5.55666447 3.76812305e-09
30 MLLT11 0.933398188 6.91408196 6.22860437e-09
31 GLRX 0.755615376 8.38524607 1.89847705e-08
32 TLK1 1.094461454 6.04144950 1.98436907e-08
33 SRXN1 1.901015981 4.26048078 2.17199613e-08
34 CTGF -0.745661932 9.04425570 2.89038572e-08
35 FGF7 -0.735019064 8.60097415 1.09978987e-07
36 PLA2G16 -0.834482951 7.48798845 1.28660013e-07
37 PRDX1 0.657867939 9.46820623 1.56827670e-07
38 GCLM 1.506969200 4.56480861 6.52523639e-07
39 SQSTM1 0.884635822 6.40235146 6.85939769e-07
40 LUM -0.619749996 10.59453999 7.47949706e-07

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Cyclosporine (CYC)
Control Samples: CTRL.3.A1, CTRL.3.B10, CTRL.3.E6, CTRL.3.K4
Drug Samples: CYC.3.F4, CYC.3.K15, CYC.3.N10
Investigative Units: U-19, 25, 28, 13, 15
Sequencing Runs: SR-3
Normalized Counts: Human.D-Hour.48-Plate.3-ReadCounts-Norm-CTRL.CYC.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 AHNAK -1.035701013 7.55827568 8.74706521e-07
2 SLC5A3 -1.769288415 5.13418844 1.60237147e-05
3 CCL11 1.033452021 6.85416923 1.68776815e-05
4 RAB23 -1.339148436 5.60614222 2.81368714e-05
5 HTR2B 0.959080703 6.92735233 3.00329500e-05
6 C15orf65 2.149104496 3.93256414 5.59908695e-05
7 PDIA3 -1.699537025 5.06201453 8.78343417e-05
8 CLUAP1 1.166375169 5.78379721 1.11494315e-04
9 SLC1A1 -2.972868283 3.42322142 1.16281377e-04
10 FBN1 -0.735313266 8.86473319 1.18211046e-04
11 CTSK 0.661435377 9.59138481 1.33805162e-04
12 CYR61 -0.800760131 7.67383433 1.54965838e-04
13 CD36 0.664718980 9.35230545 1.91853372e-04
14 ATRN -2.196639482 3.90888337 2.11691502e-04
15 ATP13A3 -0.880367790 7.06992390 2.14248600e-04
16 PALLD -0.827902665 7.29557765 2.55323758e-04
17 SERPINE2 -0.681580656 9.11441502 2.85770173e-04
18 SEPT8 -1.282124436 5.40063165 3.33930912e-04
19 FAM208B -1.835474212 4.18263973 3.53627851e-04
20 THBS1 -0.655919366 9.17931073 4.20371906e-04
21 PLIN2 0.753979622 7.39878448 4.33826208e-04
22 YAP1 -1.155294661 5.72268709 4.71978462e-04
23 EBF1 -1.604402485 4.32686408 5.05454209e-04
24 KDM3A -1.687203359 4.15944779 5.88985274e-04
25 GPC4 -2.060084962 3.62206360 5.94728941e-04
26 LOC100506795 3.072208865 2.98810751 6.53398318e-04
27 LINC00116 1.368048147 4.56268350 6.82233122e-04
28 CCL2 0.778457524 7.44222026 7.28914758e-04
29 TIMP2 -0.721098230 8.04988812 7.43967558e-04
30 SERP1 -1.132558381 5.50476159 7.77766438e-04
31 FMO2 0.909198375 6.54292066 8.32282538e-04
32 COL12A1 -0.689381223 8.21516743 8.56464243e-04
33 TNFAIP6 0.736187073 7.45168299 8.67723750e-04
34 LINC00657 -0.864727157 6.69745141 9.25788000e-04
35 SETD2 -1.485327966 4.91068337 9.47593999e-04
36 FN1 -0.556497706 11.79407087 9.80587522e-04
37 LCMT1 1.334814505 4.56684367 1.11076701e-03
38 ENC1 -1.249397497 4.70660885 1.11808011e-03
39 COL4A1 -0.599525654 9.54955289 1.12188880e-03
40 MORC4 -1.972033278 3.56547409 1.12230254e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Cytarabine (CYT)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: CYT.3.B6, CYT.3.C7, CYT.3.F24
Investigative Units: U-14, 16, 20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.CYT.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPS9 -1.232268805 9.89207351 3.71018839e-20
2 AHNAK 1.009903103 7.72658258 4.82461796e-12
3 RPL18 -0.987873247 8.62405805 5.15189684e-12
4 RPL28 -0.877804864 9.74248307 3.69981467e-11
5 CYR61 0.945934407 7.54875761 3.01518954e-10
6 RPS23 -0.673405361 13.14348158 5.77278983e-08
7 RPLP1 -0.653942687 12.09038175 1.67714521e-07
8 FTL -0.645120330 14.24917191 1.68373826e-07
9 MYEOV2 -0.863331460 7.20504490 2.55929012e-07
10 PALLD 0.832723799 6.98621109 2.56161260e-07
11 C12orf57 -0.905350414 6.87691581 3.37364887e-07
12 PRSS23 0.715757729 7.90327715 5.88974183e-07
13 FBN1 0.643455040 9.33124968 6.00054094e-07
14 SNTB2 1.392092092 4.84894689 6.31246928e-07
15 RGS5 0.756844818 7.40465778 7.20711330e-07
16 VCAN 0.639326774 8.79339141 1.43548247e-06
17 ADAMTS1 1.186881602 5.27469776 1.60029506e-06
18 PICALM 1.072601530 5.53032058 1.89304165e-06
19 ITGBL1 0.681348707 7.87983438 2.16102480e-06
20 ZFAS1 -0.610308220 10.13530335 2.31435277e-06
21 RAC1 -0.663671187 8.68167586 2.39068438e-06
22 PDIA3 1.148638258 5.32168618 2.40037814e-06
23 NUCKS1 0.679274400 7.87894412 2.44933583e-06
24 COL6A3 0.635971006 8.49858241 2.64665349e-06
25 IGFBP3 0.574146782 10.80742254 2.77675821e-06
26 GDF6 1.689527704 4.13247834 3.86392936e-06
27 RDH10 0.687685829 7.42519894 5.96580262e-06
28 COL4A1 0.626867164 8.30182528 6.09241043e-06
29 NIPA1 1.960440485 3.60220388 6.40432477e-06
30 COMT -0.628769686 8.64944156 6.40451472e-06
31 RPL10 -0.554555390 12.97483471 7.31632101e-06
32 RPLP2 -0.584274438 9.59107091 9.27433189e-06
33 SH3PXD2A 0.693436520 7.25480276 9.31784317e-06
34 ATP13A3 0.630315964 7.91404222 1.03632298e-05
35 GLS 0.703696792 7.07301530 1.06031842e-05
36 AKR1C3 -0.722228515 7.22679970 1.10184256e-05
37 OXTR 1.133106407 5.10026159 1.22763418e-05
38 DHRS3 -0.718455613 7.22261561 1.29298867e-05
39 VGLL3 0.762021902 6.59217798 1.30129823e-05
40 TPM4 0.609615347 8.15065430 1.33606577e-05

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Dasatinib (DAS)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: DAS.3.B5, DAS.3.C6, DAS.3.F23
Investigative Units: U-14, 16, 20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.DAS.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 TAGLN -1.748576639 9.32521160 8.38643483e-29
2 ACTA2 -1.525943548 12.50911946 1.07726039e-25
3 SLC40A1 1.831096914 6.21523905 1.97918477e-20
4 C5orf46 -1.383891789 9.59059440 4.70889820e-20
5 IGFBP3 -1.356891512 10.14940985 5.97036534e-20
6 TUBA1B -1.359184116 9.99065135 7.52818573e-20
7 HSD11B1 2.839281526 4.66132184 1.42941399e-18
8 SH3BGR -1.476266746 7.87660001 3.18027378e-18
9 SERPINE1 -1.437455694 8.03191726 6.75070223e-18
10 IL33 2.353196756 4.99689501 3.19485507e-17
11 FMO2 1.818386007 5.73816899 1.92408893e-16
12 EVI2A 1.896206993 5.43830638 4.13129045e-15
13 PLIN2 1.116232008 8.37852302 4.84331988e-14
14 CLEC2B 1.083266672 8.28162394 3.90038186e-13
15 ABCA9 1.438483687 6.15315235 4.90591145e-13
16 PDE4B 5.387392475 2.98155381 9.43560459e-13
17 IFITM1 1.234764049 6.70398665 3.81032666e-12
18 LOC645638 -1.680723703 5.82451667 5.10296424e-12
19 TNFAIP6 -1.136779649 7.72325609 1.73511889e-11
20 TUBA1A -1.005375662 8.90432711 5.89646526e-11
21 KRT18 -1.105104887 7.54517312 1.16278689e-10
22 PSAT1 -1.108100175 7.48201920 1.40290530e-10
23 TFPI 0.921576596 8.94219158 1.44671950e-10
24 ASNS -1.113771929 7.41417393 1.52223231e-10
25 C10orf10 1.129495914 6.69625634 1.94959810e-10
26 TPM2 -1.008118599 8.34435339 2.03585570e-10
27 DDAH1 -1.229099430 6.59524786 5.12419266e-10
28 EDN1 1.551633827 5.25693472 5.92701634e-10
29 TFPI2 1.914074596 4.51366256 1.71095646e-09
30 CCRL1 1.228503472 5.91655049 3.39947594e-09
31 ANKRD1 -1.237800995 6.30427143 4.26069780e-09
32 TNFSF10 3.118097979 3.23520770 4.37399240e-09
33 SOD2 1.346716571 5.53442411 4.65966882e-09
34 LAMA4 1.657504594 4.83003684 5.29160592e-09
35 ANXA2 -0.830683946 11.21612492 5.73653539e-09
36 LOC100505633 -1.023827668 7.26171935 6.45479744e-09
37 MYL6 -0.808876813 12.57156642 9.59569939e-09
38 PDGFD 1.806486277 4.50737878 1.35346437e-08
39 PTS -0.860615043 8.71289275 2.21003852e-08
40 RPS9 -0.796157165 9.94589327 4.85595101e-08

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Dasatinib + Cytarabine (DAS+CYT)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: DAS+CYT.3.B7, DAS+CYT.3.C8, DAS+CYT.3.G1
Investigative Units: U-14, 16, 20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.DAS+CYT.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 TAGLN -1.947905073 9.35255146 2.44205631e-37
2 ACTA2 -1.672374907 12.53958909 1.58552617e-33
3 TUBA1B -1.679292628 9.99069763 3.06322617e-31
4 SH3BGR -1.815619902 7.88518092 9.50781389e-26
5 C5orf46 -1.491402527 9.62703253 8.60967766e-25
6 SLC40A1 1.943026543 6.33341099 5.41884047e-24
7 SERPINE1 -1.656626647 8.05243521 1.27758950e-23
8 IGFBP3 -1.354010429 10.20599970 1.10425708e-21
9 HSD11B1 2.937847931 4.77014889 1.52452812e-20
10 TNFAIP6 -1.565801139 7.70159007 1.01203731e-19
11 TUBA1A -1.339758194 8.89069590 7.43330258e-19
12 LOC645638 -2.221522440 5.82112794 4.56778237e-17
13 PSAT1 -1.440614589 7.47812620 3.03470291e-16
14 IL33 2.263805166 4.97056720 9.01869237e-16
15 SOD2 1.703269197 5.79445148 6.43772743e-15
16 KRT18 -1.339385847 7.55764703 7.10951756e-15
17 MYL6 -1.037227975 12.57130087 1.22058782e-14
18 TPM2 -1.189835233 8.35931120 1.22776482e-14
19 ANXA2 -1.049583636 11.21921239 1.60489397e-14
20 PLIN2 1.094654593 8.41964480 1.64254021e-14
21 S100A10 -1.087259422 9.22660274 6.41762842e-14
22 PDE4B 5.589498366 3.14473560 7.54580619e-14
23 PLK2 1.345468501 6.58996002 8.82891105e-14
24 ASNS -1.274176362 7.44356413 3.99933624e-13
25 PTS -1.092425566 8.71648476 5.43237657e-13
26 FMO2 1.586067840 5.63206488 2.02189425e-12
27 LOC100505633 -1.233371776 7.27910125 5.75840157e-12
28 ANKRD1 -1.471169722 6.32445655 9.57313167e-12
29 EVI2A 1.687673400 5.34242701 1.12087318e-11
30 MYL12A -0.918858968 11.01015122 1.54622667e-11
31 GPR1 -1.217195311 7.10187716 1.84556278e-11
32 S100A11 -0.926613533 10.24251853 2.25157622e-11
33 ENO1 -0.910692406 10.38440250 4.18312785e-11
34 IGFBP4 1.116752555 6.91805024 4.82122106e-11
35 LAMB1 1.299365300 6.13133360 9.79444012e-11
36 RPS9 -0.890695004 9.97733030 1.70172534e-10
37 WARS -0.990688696 8.28215426 2.14300014e-10
38 CYCS -0.955875487 8.57607373 2.62955626e-10
39 CYBRD1 0.931973000 8.05323083 2.69813810e-10
40 SEC61G -0.858451351 10.60977966 3.65560588e-10

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Dasatinib + Methotrexate (DAS+MTX)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: DAS+MTX.3.B9, DAS+MTX.3.C10, DAS+MTX.3.G3
Investigative Units: U-14, 16, 20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.DAS+MTX.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 TAGLN -1.952927623 9.31533557 1.73992745e-39
2 ACTA2 -1.687630942 12.50403509 2.94098993e-35
3 C5orf46 -1.402669250 9.60897468 4.05566882e-23
4 TUBA1B -1.340639183 10.01682735 7.85108788e-22
5 HSD11B1 2.972253301 4.78688790 1.37807013e-21
6 SH3BGR -1.446318724 7.90443536 3.56128431e-19
7 KRT18 -1.448776360 7.49770633 8.20548371e-18
8 SLC40A1 1.683867249 6.12928680 1.20672977e-17
9 EVI2A 1.977691402 5.50723163 2.48904149e-17
10 IGFBP3 -1.158636513 10.21283481 4.82921387e-17
11 PSAT1 -1.436444225 7.44719345 2.81508002e-16
12 LOC645638 -2.062758496 5.79604589 3.82345351e-16
13 SERPINE1 -1.277846675 8.08852494 9.63699869e-16
14 TUBA1A -1.120945443 8.89973639 1.30333293e-14
15 FMO2 1.659072164 5.64937144 7.34709892e-14
16 CLEC2B 1.052751186 8.28315474 1.19903047e-13
17 PLIN2 1.024330827 8.34641054 3.91375095e-13
18 C10orf10 1.220602457 6.76346434 9.85696633e-13
19 ANXA2 -0.944872246 11.21018961 1.52518177e-12
20 PDE4B 5.325365184 2.95303696 4.95422117e-12
21 IFITM1 1.183178020 6.68928920 9.48801317e-12
22 TNFAIP6 -1.120486435 7.75530169 1.01292560e-11
23 TPM2 -1.007954726 8.36361553 1.22771322e-11
24 MYL6 -0.885263786 12.57414354 1.52835367e-11
25 IL33 1.964825532 4.75077175 1.59550624e-11
26 NPR3 -1.220412402 6.86096019 1.60711644e-11
27 ANKRD1 -1.412202376 6.29525293 1.71567731e-11
28 PTS -0.959635002 8.71041457 5.01876804e-11
29 PDE7B 2.845922258 3.70438268 1.79649470e-10
30 LAMA4 1.753787078 4.90724201 2.13924157e-10
31 DDAH1 -1.166599661 6.62296546 2.64375055e-10
32 S100A10 -0.883797657 9.23922419 3.07183761e-10
33 MYL12A -0.830948846 10.99832001 4.32959988e-10
34 RPS9 -0.841476796 9.95600079 6.84747142e-10
35 ABCA9 1.224520918 6.04045104 1.05309269e-09
36 YWHAG -1.025393914 7.19916350 1.36870149e-09
37 LOC100505633 -1.052683138 7.28416606 1.63991369e-09
38 MYH10 -0.837540382 9.25756026 1.93073926e-09
39 CD44 1.074680579 6.51265025 2.33982686e-09
40 EVI2B 3.450432269 3.20451515 3.06274189e-09

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Domperidone (DOM)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: DOM.3.E3, DOM.3.G15, DOM.3.I16
Investigative Units: U-18, 21, 23, 12
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.DOM.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL18 -2.470978861 9.79231021 2.34109279e-39
2 RPLP2 -1.816786955 10.66157403 4.97505610e-24
3 MT2A -1.017447313 8.90402914 7.47640451e-09
4 RPLP1 -0.877887864 12.52307147 4.44001449e-07
5 MTM1 -2.565424187 3.86824465 8.46315915e-07
6 LBH -0.731572212 7.83729713 5.27810922e-05
7 CD55 1.254240431 4.43718373 9.56096019e-05
8 SLC2A3 -0.800946473 6.70886442 1.40679832e-04
9 CTGF 0.626287386 9.90328916 1.76569017e-04
10 SH3PXD2A 0.715155788 6.74074630 1.86133879e-04
11 MTUS1 -1.381431152 4.33424514 1.87388528e-04
12 ZNF616 1.611414994 3.53779434 2.38246397e-04
13 TMEM220 2.088696751 2.58394468 3.05833339e-04
14 TMEM167B -1.009166687 5.18977150 3.47804809e-04
15 OGN 0.638343886 7.27609489 4.32126023e-04
16 PTRF 0.654472153 7.18663228 4.33740687e-04
17 NUP155 -1.610714687 3.82522250 4.38610638e-04
18 BMPR2 0.858189153 5.53413771 4.54726910e-04
19 ITGBL1 0.687969341 6.34124439 4.67928198e-04
20 S100A4 0.609228176 7.88915316 5.39900097e-04
21 PTDSS2 -5.304011527 2.13405959 5.88181307e-04
22 HSD17B11 -0.746741784 6.47448981 6.18005480e-04
23 MZT1 -1.388664124 4.04239827 8.85861407e-04
24 TIMP3 0.567667245 7.56485383 9.50728196e-04
25 LTA4H -0.592220035 7.98132267 9.50971691e-04
26 ZNF232 -2.106446034 3.18627236 1.07986931e-03
27 FMNL2 1.108089599 3.81412759 1.24005695e-03
28 GCA -1.171948128 4.48877941 1.28216485e-03
29 RHOD 1.494711259 3.26061031 1.31476076e-03
30 LOC100506388 1.885699605 2.82887600 1.34549391e-03
31 STXBP5 0.887508214 4.89141988 1.35065728e-03
32 NCOR1 0.903266954 4.80560483 1.37179196e-03
33 AFAP1 1.034852139 4.59575946 1.47896284e-03
34 ZRANB3 -3.289369509 2.28050531 1.61555539e-03
35 FOXN3 1.080503657 4.52944220 1.64633224e-03
36 TSPAN12 1.992138404 2.51481822 1.70176616e-03
37 SBF2-AS1 -1.491915293 3.64659276 1.75869216e-03
38 ATP2B1 0.714625180 5.89008860 1.78461970e-03
39 TPM4 0.539445230 8.35790347 1.80764070e-03
40 ROR1 0.873434617 5.00135660 1.90288211e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Domperidone (DOM)
Control Samples: CTRL.3.A1, CTRL.3.B10, CTRL.3.E6, CTRL.3.K4
Drug Samples: DOM.3.F1, DOM.3.K21, DOM.3.N12
Investigative Units: U-19, 25, 28, 13, 15
Sequencing Runs: SR-3
Normalized Counts: Human.D-Hour.48-Plate.3-ReadCounts-Norm-CTRL.DOM.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 NSA2 1.480636570 7.94388720 2.48374177e-14
2 CTSK 1.033785790 9.78155165 9.06417661e-09
3 RPLP2 1.021606311 9.77848593 1.40866361e-08
4 RPLP1 0.977055994 12.27088355 3.12240422e-08
5 GLIS3 -1.847480243 3.65597288 2.87262928e-05
6 RAC1 -0.798397521 8.67231124 3.41634097e-05
7 OXTR -1.107481173 5.39009994 8.43792028e-05
8 RPS27A 0.685593808 12.53170247 1.01613326e-04
9 CD36 0.704172234 9.35896868 1.02034783e-04
10 SYNM -1.475755642 4.02105945 1.28046161e-04
11 FAM69A 0.752830510 7.60396206 1.60218770e-04
12 PSG5 0.945394048 5.95885474 1.76019387e-04
13 SNF8 -0.924292320 6.03461397 2.13544193e-04
14 KIAA1656 1.967209198 3.25206629 2.13671703e-04
15 B4GALT6 -2.534512221 2.45984666 2.32861722e-04
16 ZNF654 -1.564873289 3.50832204 2.46082705e-04
17 ID1 1.930515284 3.69666099 2.61057911e-04
18 AFF1 -1.202895802 4.54865351 4.15098778e-04
19 NCKAP1 -0.885717448 5.76350794 5.04576533e-04
20 ZNHIT1 -0.788579254 6.85538105 5.06118727e-04
21 TAF13 1.570603299 3.99646859 5.15507696e-04
22 EXT2 -1.015029430 5.26439692 5.17198757e-04
23 ST3GAL2 1.292154586 4.54179263 5.30221762e-04
24 CLUAP1 0.904740141 5.66227924 6.18224995e-04
25 NUMA1 1.028995010 5.25604102 6.20125205e-04
26 IGF1 0.723291038 6.54272981 7.77093434e-04
27 MSANTD4 1.231006856 4.54238413 8.33244645e-04
28 HTR2B 0.699589089 6.78918434 8.48542062e-04
29 ANTXR1 -0.764912290 6.41115866 8.62136661e-04
30 CCT7 0.946742206 5.26352850 1.02079599e-03
31 SS18L1 -1.504226129 3.34059691 1.11876819e-03
32 ATRN -1.587148390 3.60153630 1.14338529e-03
33 FSCN1 2.430370154 2.96082912 1.14593756e-03
34 ETS1 -1.190841069 4.20523018 1.14734326e-03
35 RFWD2 -1.385659458 3.72993328 1.50046909e-03
36 SNX1 -0.911457739 5.00764860 1.66783073e-03
37 APOBEC3C 0.715433122 6.36085714 1.66884461e-03
38 HECTD1 -0.935906702 5.36653120 1.68869851e-03
39 HEATR1 1.373456568 4.05871373 1.73760558e-03
40 SNX24 1.007834535 4.81686699 1.75683114e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Diethylpropion (DTP)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: DTP.3.D11, DTP.3.D21, DTP.3.G9
Investigative Units: U-17, 18, 21, 23, 12
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.DTP.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL18 -2.773814387 9.78035548 9.44805182e-50
2 RPLP2 -2.286882989 10.61227973 4.24952428e-37
3 RPLP1 -1.425516708 12.40991550 2.09559435e-16
4 MT2A -1.114991043 8.89772294 1.06566948e-10
5 HMGCS1 -1.135722229 6.38175095 1.18408492e-07
6 LBH -0.874459129 7.80482927 4.76049545e-07
7 RPS24 -0.785907212 11.48649424 3.45020237e-06
8 NSA2 -0.816079211 7.26588940 6.88888317e-06
9 INSIG1 -1.169882816 5.01020032 7.04158424e-06
10 HTR2B -0.794727125 7.85162472 7.55403696e-06
11 SH3PXD2A 0.806761755 6.82302818 1.03905621e-05
12 RPL28 -0.743672184 9.23495085 1.48548397e-05
13 PPAP2B -0.900967269 6.16690119 1.63557919e-05
14 IDI1 -0.744429478 8.77684698 1.81188601e-05
15 KRT18 0.785608528 6.59037764 2.34381133e-05
16 RPL7A -0.701245010 11.26445998 3.22265329e-05
17 SCD -0.762427132 7.19946570 3.42797293e-05
18 RPS19 -0.687867671 11.99788178 4.72880156e-05
19 GPX1 -0.903440660 5.82188293 4.77063732e-05
20 IFIT2 -0.880336331 5.85442986 6.12677107e-05
21 RPS15 -0.676023929 9.84868568 6.49738388e-05
22 RPS4X -0.660605015 13.03441523 9.68682586e-05
23 RPS28 -0.660998017 9.23416595 9.98325979e-05
24 TIMM9 -0.748874128 6.46593243 1.59323619e-04
25 MSMO1 -0.640411492 9.33077635 1.86263729e-04
26 DSP 0.853374017 5.58338824 1.90490506e-04
27 ARFGAP1 1.666918191 3.03525552 1.92286134e-04
28 ZFP90 1.298882596 3.38618345 2.14744018e-04
29 TIMP3 0.603354996 7.61275859 2.91591311e-04
30 RCN3 0.776482430 5.71790260 3.60529297e-04
31 MYH11 0.611357977 7.71445943 4.34767260e-04
32 SLC40A1 -0.644987165 7.02800397 5.32290911e-04
33 LYRM4 -0.816377543 5.53166081 5.47106042e-04
34 EAF1 1.011719235 4.09738961 6.80703805e-04
35 BMP1 1.324609292 3.32882725 6.86842692e-04
36 ERBB2 1.791166021 2.57988601 7.13074925e-04
37 UBASH3B 2.571312854 1.99348298 7.33651754e-04
38 LPAR6 -0.806151137 5.28927232 7.42208792e-04
39 PTGIS 0.618740709 6.95744443 7.52604325e-04
40 CLEC2B -0.671652772 6.62812235 7.87149430e-04

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Diethylpropion (DTP)
Control Samples: CTRL.3.A1, CTRL.3.B10, CTRL.3.E6, CTRL.3.K4
Drug Samples: DTP.3.B12, DTP.3.E12, DTP.3.K9
Investigative Units: U-15, 19, 25, 13
Sequencing Runs: SR-3
Normalized Counts: Human.D-Hour.48-Plate.3-ReadCounts-Norm-CTRL.DTP.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 COG3 -2.242756653 3.78545638 0.000190462924
2 IGFBP3 0.693655484 9.61168447 0.000381935310
3 ID4 1.081159217 5.50585568 0.000477086043
4 DYNC1H1 0.916092873 6.01019147 0.000556692887
5 MT2A -0.677018782 9.52273392 0.000665705748
6 ST6GALNAC4 2.643390221 3.11829214 0.000678321095
7 IGF2BP1 4.991731922 2.44088760 0.000684385358
8 FAM126B 1.659536672 3.95254233 0.001109789828
9 LNP1 2.737746339 2.93396418 0.001664498838
10 TESK1 -2.362300677 3.37303955 0.001886289517
11 HMGB2 -0.653146564 8.07484079 0.001913727810
12 RASSF3 0.859866936 5.81616934 0.002034034792
13 SUZ12 1.521609667 4.08993562 0.002177912092
14 RTTN -2.863894337 2.84175073 0.002505308259
15 CLN3 -3.627237076 2.83514017 0.002536087537
16 TBC1D10B -2.137110676 3.42548192 0.002578316552
17 ATF7IP -1.829965639 3.64857692 0.002830647035
18 LINC00667 1.194140243 4.46736718 0.003109050780
19 MOXD1 1.106876952 4.75496392 0.003309835227
20 GATA6-AS1 3.409656443 2.54281926 0.003484218789
21 SUCLG2 1.088004935 4.82633211 0.003689764734
22 ZC3HAV1 0.931569946 5.13176032 0.003942821973
23 NIPSNAP3B 1.590177527 3.56794157 0.003948162546
24 GALNT1 0.715230948 6.37095214 0.004063491028
25 MT1X -0.862493356 5.66003921 0.004097869913
26 GALC 2.878893298 2.71889540 0.004102812889
27 SCAND2P -1.952298962 3.48472692 0.004148163092
28 GYS1 -1.881231732 3.39336747 0.004410659406
29 NEK7 0.713050265 6.39665588 0.004611968946
30 TMEM135 -1.238211060 4.27055182 0.004695802650
31 MLLT4 1.895511525 3.35108719 0.004950360129
32 PTK7 -1.325821532 4.41322336 0.005205599667
33 ITGA2 -1.980977241 3.47625185 0.005303285228
34 AR 2.162136783 3.06808799 0.005404503716
35 PLAC9 -0.665592783 6.99595166 0.005439686247
36 PCYOX1L 1.743210546 3.51419864 0.005734862652
37 TAOK2 -4.846867098 2.49601767 0.005792756091
38 CRX -1.540410894 3.75814076 0.006010687800
39 COMT -0.566191506 8.47096874 0.006167680866
40 VGLL3 0.628124291 7.02324200 0.006178564958

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Entecavir (ENT)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: ENT.3.D9, ENT.3.D19, ENT.3.G7
Investigative Units: U-17, 18, 21, 23, 12
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.ENT.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL18 -2.561232914 9.78343224 5.59655917e-44
2 RPLP2 -2.192179362 10.60387170 2.69837452e-34
3 RPLP1 -1.320041869 12.41224862 3.29698482e-14
4 HMGCS1 -1.106520207 6.36248627 1.13649246e-07
5 IDI1 -0.705157793 8.76424331 3.46004650e-05
6 GPX1 -0.886989937 5.79927003 3.65920886e-05
7 SCD -0.714791507 7.18553484 4.91692493e-05
8 DHRS3 0.988198816 4.99258821 1.13923056e-04
9 RPS24 -0.651458516 11.50767606 1.23226568e-04
10 NSA2 -0.679924011 7.28859421 1.35629820e-04
11 MSMO1 -0.645687039 9.30673320 1.49876987e-04
12 HMGCR -0.715477543 6.70763904 1.60613959e-04
13 C2orf49 -1.348461563 3.42038750 2.21145546e-04
14 INSIG1 -0.996829993 5.05361686 2.52172205e-04
15 ANGPTL4 1.146738372 4.22748885 2.91163001e-04
16 DUSP14 -1.066920418 4.04490191 2.95017655e-04
17 C14orf1 -0.801816147 5.54863165 5.32929794e-04
18 PGAM2 -1.005010841 4.30387565 5.56905163e-04
19 MCM6 1.546621531 3.23389972 6.91512327e-04
20 RPL28 -0.584148612 9.26682275 6.96110635e-04
21 RPS28 -0.549778313 9.25060259 1.19480705e-03
22 TMEM177 2.044103452 2.25785347 1.25801225e-03
23 SAMM50 0.798278188 5.16858235 1.38577540e-03
24 PSPC1 -1.314529299 3.07405818 1.39140880e-03
25 GNRH1 4.932360576 1.17620011 1.42059375e-03
26 CAMKK1 3.577657294 1.48882479 1.49227414e-03
27 B3GAT3 2.052612875 2.12048879 1.61503834e-03
28 RPS19 -0.534290154 12.02769281 1.63202044e-03
29 IGFBP4 0.631820804 6.25130140 1.85923677e-03
30 RPS4X -0.529541055 13.05708297 1.87392411e-03
31 TMEM150A 2.854857233 1.84466757 2.02381642e-03
32 WDR20 -0.797920052 4.71697663 2.07955485e-03
33 RPL7A -0.518200478 11.30385671 2.12996002e-03
34 RAPGEF6 -1.342944177 2.95230826 2.17323688e-03
35 SIK3 -2.383446085 1.89847346 2.32655172e-03
36 TMEM167B -0.712733758 5.21082513 2.38423219e-03
37 RPS15 -0.510617565 9.88337172 2.54631421e-03
38 CYTH1 3.379540425 1.33521971 2.59869724e-03
39 C11orf49 1.082656301 3.72581530 2.81672960e-03
40 FANCF 1.439367208 2.87178670 2.87459395e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Erlotinib (ERL)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: ERL.3.F11, ERL.3.H10, ERL.3.J11
Investigative Units: U-20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.ERL.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL28 -0.773378965 9.73365961 8.91574144e-08
2 RPS9 -0.756663578 9.96389385 1.77636544e-07
3 RPL18 -0.759056579 8.64479348 5.67397468e-07
4 ZNHIT1 -0.775663338 6.98150068 1.40981265e-05
5 RPLP1 -0.564736854 12.08022496 5.08307878e-05
6 ZNF362 -1.347174968 4.41808638 9.54434204e-05
7 CCL11 -0.698796972 6.88537248 1.21468347e-04
8 MMP1 1.006447132 4.85952064 1.34873250e-04
9 CPSF4 2.610964370 2.44140545 1.48723914e-04
10 APPL2 1.550047372 3.38681413 2.20736033e-04
11 RAC1 -0.545969341 8.67754647 2.34150066e-04
12 RPLP2 -0.527847674 9.57211024 2.56649250e-04
13 GATC 1.239978606 4.04880108 2.79063142e-04
14 DPP4 0.597898320 6.75157857 4.12104237e-04
15 RPS26 -0.524650034 8.72757483 4.24462590e-04
16 CCL2 -0.548127043 7.87998749 4.79188813e-04
17 OXTR -1.110603454 4.19734964 5.90677679e-04
18 STX10 -1.285492607 3.71249270 6.03951493e-04
19 SAFB 1.325419744 3.69554629 6.69565465e-04
20 DZANK1 1.832036338 2.88987792 7.29865274e-04
21 NSA2 0.493980432 7.66298662 7.88587609e-04
22 OAF 1.545273433 3.21592212 8.48632164e-04
23 WHSC1 1.602210337 3.07103360 9.39231141e-04
24 NDUFAB1 -0.659325886 6.23142461 1.03145719e-03
25 MYO5A 1.160485214 4.01023973 1.05855876e-03
26 C6orf62 0.512304927 7.61148615 1.07639958e-03
27 BCAT2 -2.106073239 2.44619845 1.09479013e-03
28 COL16A1 -0.685915142 5.39845936 1.14178623e-03
29 ACP2 -2.199452611 2.57699583 1.16320482e-03
30 KIAA1407 1.449626309 3.28638677 1.16468749e-03
31 TXNDC17 -0.525631741 7.65954318 1.23322200e-03
32 TTK 4.689714812 1.57548692 1.24533561e-03
33 NAALADL2 -2.668112448 2.23495815 1.31349002e-03
34 SNHG15 -0.954623709 4.75217507 1.36464666e-03
35 PBX1 1.108244082 3.96559967 1.40877619e-03
36 SLC44A1 0.997290875 4.37955414 1.43852395e-03
37 STAG3L4 2.081551533 2.50428208 1.54563529e-03
38 PPT2 -3.528312722 1.95400627 1.59251439e-03
39 C3orf52 -2.785098304 2.35036278 1.60451929e-03
40 CIC 3.432005529 1.79692684 1.66279278e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Erlotinib + Cefuroxime (ERL+CEF)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: ERL+CEF.3.F13, ERL+CEF.3.H12, ERL+CEF.3.J13
Investigative Units: U-20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.ERL+CEF.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 NQO1 3.78865689 7.96135667 4.69155470e-130
2 HMOX1 5.72337383 6.40329338 4.09770591e-115
3 AKR1B10 5.38732572 6.23204129 3.65902946e-101
4 AKR1C3 2.82087397 9.09582140 7.62677856e-100
5 PTGR1 2.73063266 8.31917571 7.21168542e-84
6 AKR1C1 3.96985795 6.14767327 2.26977919e-71
7 AKR1C2 4.10797881 5.78982035 3.92408193e-62
8 TXN 1.95021043 12.11657083 9.82250488e-61
9 SLC7A11 3.14815307 6.26127912 2.77579467e-55
10 FTL 1.67900994 15.26522048 2.76512369e-47
11 MGST1 1.69245041 10.15875650 2.41056604e-43
12 CDK5RAP2 2.35388714 6.61135393 2.57735757e-41
13 TXNRD1 1.63792739 9.65362999 2.80331751e-39
14 FTH1 1.53106098 10.79618860 7.50906000e-37
15 GSTM3 1.68603083 7.99771327 1.95454817e-33
16 TNFRSF11B -1.68039450 9.04469655 5.67466494e-32
17 GLRX 1.53379447 8.81006651 6.10159814e-32
18 IGF1 -1.75470334 8.22581043 4.22938026e-30
19 RPS9 -1.52961472 9.77028141 9.37144365e-30
20 AFP 4.98409657 4.14154579 1.86956359e-26
21 PGD 2.06541758 6.03118551 1.38213126e-25
22 IGFBP3 -1.30229465 10.13800634 5.60733090e-23
23 PRDX1 1.20911469 9.74415128 2.47857868e-22
24 CTSL 1.40230019 7.52584871 1.84207370e-21
25 CTGF -1.34612741 8.88883338 1.84640149e-21
26 INHBA -2.09506202 6.13282460 2.52728288e-21
27 SQSTM1 1.56357326 6.77648879 2.78359118e-21
28 AKR1B1 1.77064952 6.17131575 5.05137513e-21
29 CFHR1 3.78768014 4.07861242 2.14978405e-20
30 TDP2 1.89688087 5.68904111 6.68992998e-19
31 SRXN1 2.59662114 4.72930620 5.40654976e-18
32 HGD 2.47196601 4.82982642 9.85624423e-18
33 ANKRD1 -1.82604827 6.17918076 1.18566548e-17
34 TAGLN -1.14509205 9.41270955 1.56171367e-17
35 ACTA2 -1.05397884 12.58123238 4.30836672e-17
36 TKT 1.87178329 5.50903078 5.69428638e-17
37 IDH1 1.12090795 8.18848819 2.59271064e-16
38 FGF7 -1.16601404 8.48062271 5.48610138e-16
39 TIMP3 -1.12122289 9.00584843 5.59869719e-16
40 TPM1 -1.26518783 7.69621116 5.90157198e-16

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line E (LPC-1004)
Drug Treatment: Flecainide (FLE)
Control Samples: CTRL.3.L4, CTRL.3.M4, CTRL.3.M5, CTRL.3.N18
Drug Samples: FLE.3.L9, FLE.3.L10, FLE.3.M10, FLE.3.M11
Investigative Units: U-26, 27, 29
Sequencing Runs: SR-3
Normalized Counts: Human.E-Hour.48-Plate.3-ReadCounts-Norm-CTRL.FLE.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 DHRS3 -2.858575503 5.26436731 4.60355742e-22
2 MT2A -1.440092967 8.82911735 2.71700312e-18
3 TAF1D 1.341661341 5.75390633 5.02046029e-09
4 ADH1B -0.944338521 9.04089313 5.07110514e-09
5 IFITM1 -0.911535009 8.38211891 8.46504580e-08
6 MYOZ2 1.421216841 5.30184926 1.68871739e-07
7 NEGR1 1.803156678 4.40316051 4.32494622e-07
8 SLMAP 1.109974219 6.42091980 5.99883214e-07
9 ACTA2 0.688097375 14.41371742 2.01122163e-06
10 NTRK2 1.148366648 5.70952087 2.69487442e-06
11 ELN 0.961823527 6.65729903 3.52010203e-06
12 STK38L 0.884905663 7.22969195 3.78250023e-06
13 DAPP1 1.530271040 4.85068069 6.69313294e-06
14 IFIT2 -1.077217813 5.89194883 8.92272855e-06
15 COL8A1 0.795202027 7.64467383 1.24321538e-05
16 FABP4 -1.471898795 4.57107015 1.81408073e-05
17 HDAC9 1.542961223 4.56975340 2.22387814e-05
18 MAP3K7CL 0.655579566 9.24748276 3.56865811e-05
19 MT1X -1.085744269 5.34541249 3.94786979e-05
20 TNFAIP6 0.713211694 8.01285002 4.42686533e-05
21 IGFBP5 0.683759622 8.31746293 4.76434240e-05
22 FMO2 -0.938451470 6.12189270 4.87792939e-05
23 IFITM3 -0.643193595 8.81842234 7.34943912e-05
24 LUM -0.594833784 10.78660488 7.97201912e-05
25 KCNAB1 0.992811939 5.74928624 9.27532331e-05
26 CDIPT -1.406724204 4.38768738 1.21338579e-04
27 NSA2 -0.679438372 8.16405661 1.27405567e-04
28 REPS1 3.154430354 2.69430215 1.45535415e-04
29 TMEM97 1.264824013 4.86555226 1.69536498e-04
30 TARSL2 3.710949914 2.48733890 1.96557973e-04
31 DNAJC6 5.292476948 2.22974919 2.04152248e-04
32 IFIT1 -0.938576937 5.78956681 2.10545950e-04
33 FGF7 -0.741063299 6.72512765 2.58706448e-04
34 RPS28 -0.578672511 9.48879939 2.90051957e-04
35 AKR1C3 -0.656471355 7.49548299 3.12227666e-04
36 NUAK1 1.106148857 4.85644012 3.57471769e-04
37 PDGFRL -1.271272663 4.30888356 3.83590227e-04
38 MSRB3 0.628384602 7.75311451 4.00329692e-04
39 PET117 -3.167484553 2.26482682 4.43858071e-04
40 MRPL10 -1.384814528 3.78358293 4.56731277e-04

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Imatinib + Cyclosporine (IMA+CYC)
Control Samples: CTRL.3.A1, CTRL.3.B10, CTRL.3.E6, CTRL.3.K4
Drug Samples: IMA+CYC.3.F5, IMA+CYC.3.K16, IMA+CYC.3.N11
Investigative Units: U-19, 25, 28, 13, 15
Sequencing Runs: SR-3
Normalized Counts: Human.D-Hour.48-Plate.3-ReadCounts-Norm-CTRL.IMA+CYC.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPLP1 1.096195327 12.34022699 7.62577816e-09
2 HTR2B 1.293166496 7.13747406 1.10559737e-08
3 RPL18 1.130313708 8.52327148 2.55726731e-08
4 CCL11 1.253522002 6.99887620 7.41963693e-08
5 RCAN1 -1.232602392 6.80961167 7.32473574e-07
6 FMO2 1.159299040 6.70247801 2.79604298e-06
7 SOX4 1.014645901 7.48072377 6.18372802e-06
8 SLC40A1 0.969279940 7.49697232 9.93246708e-06
9 CTSK 0.818315354 9.65148841 2.65110939e-05
10 MT2A 0.784958298 10.09864337 5.11264970e-05
11 RPL6 0.751861860 12.77802119 7.15613727e-05
12 OXTR -1.391347357 5.42698117 7.43768906e-05
13 AHNAK -0.912458931 7.56133357 7.80045515e-05
14 CD36 0.763599324 9.38868696 1.00808314e-04
15 STMN1 1.303751391 5.15887822 1.10495777e-04
16 CRIP1 -2.022447459 4.09453850 1.17892160e-04
17 C10orf10 1.030139235 5.96031226 1.62279518e-04
18 RPS4X 0.710567519 13.19367141 1.73291269e-04
19 CCDC23 1.105004676 5.69418396 2.04260420e-04
20 MAP9 1.328612074 5.01619167 2.19397119e-04
21 TGFBI -1.125894084 5.65056897 2.90794023e-04
22 NUMA1 1.174815951 5.33616525 3.34459824e-04
23 RCN3 -1.027082122 5.97899034 3.70034032e-04
24 RPL7A 0.673430772 11.47139647 4.06504768e-04
25 RGS3 -1.121093986 5.59734358 4.17550196e-04
26 ATRN -1.987451306 3.82718823 4.36952978e-04
27 PTX3 0.827828474 6.79378618 4.72330795e-04
28 IRF2 0.842198136 6.49371088 5.82955641e-04
29 ANTXR1 -0.895000434 6.41728950 7.36750712e-04
30 FRAS1 -3.808997941 2.88046042 8.81843141e-04
31 SLC35A1 0.847708950 6.19632342 1.07345128e-03
32 SLFN5 1.136687637 5.00385295 1.07473092e-03
33 SELT 0.730675976 7.22255632 1.09572230e-03
34 COL12A1 -0.698470471 8.17483331 1.17855359e-03
35 MLEC -1.242571664 4.99902381 1.20184073e-03
36 BCOR -2.315251251 3.57647597 1.34262298e-03
37 RPL28 0.625768246 9.52804380 1.36562437e-03
38 MYH10 -0.640686384 9.23998548 1.49769072e-03
39 FAM134B 1.932477527 3.38478604 1.55711649e-03
40 CLDN11 1.303177751 4.57622272 1.56636951e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Lapatinib (LAP)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: LAP.3.D4, LAP.3.D17, LAP.3.P17
Investigative Units: U-17, 18, 12, 23
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.LAP.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL18 -2.482029822 9.82807471 9.68390885e-38
2 RPLP2 -2.038305012 10.65024100 1.65478782e-28
3 RPLP1 -1.197301455 12.45988353 7.33632794e-12
4 TXNIP -1.358734368 7.38529323 9.28039074e-11
5 IGFBP5 -1.171209453 8.43294279 2.58973358e-09
6 SLN -1.092995553 7.42715966 5.97749815e-07
7 PTX3 0.879534195 7.21136835 1.33109337e-05
8 UBXN2B 1.234704532 4.78234394 2.50126852e-05
9 PPP1R3C -0.839586729 7.45165031 3.29566046e-05
10 ZNF664 1.610144882 4.03246311 4.46273707e-05
11 S100A10 -0.738556451 8.29884856 4.96965957e-05
12 SCD 0.730116034 7.85656829 5.70781001e-05
13 MED4 -0.770233460 7.08266873 1.22187372e-04
14 EVI2A 1.731465864 3.65924265 2.19792775e-04
15 CDR1 -1.049334247 6.02883071 2.20322496e-04
16 RPS24 -0.630546617 11.53575943 2.34598684e-04
17 LDHA -0.633358145 11.29710068 2.63024482e-04
18 TUBA1B -0.637525508 10.05356551 2.77754326e-04
19 MT1F 1.733232479 4.15211455 2.82611297e-04
20 KDELR3 -1.059747200 5.27017331 3.99992872e-04
21 HBS1L -0.755811208 7.04162188 4.62049045e-04
22 MT2A 0.621536816 9.57356466 4.62556569e-04
23 TPP1 0.826099438 6.08600807 4.98283307e-04
24 CMAHP -1.159984284 4.48447433 5.22409025e-04
25 TXNRD1 -0.633135286 8.63931901 6.05440184e-04
26 SEC31A -0.626778558 8.22841228 6.09956387e-04
27 C21orf91 1.956470921 2.63259105 6.29300935e-04
28 HIP1 1.207249626 4.47255474 7.14810889e-04
29 SPICE1 -1.582690455 3.72076094 7.65140828e-04
30 FAM13C -0.752784268 5.54944648 8.66922756e-04
31 ACAD8 1.426798669 3.13717813 8.91344060e-04
32 VAT1 1.043325988 4.70572399 9.24686949e-04
33 GDF15 0.988940516 5.23955077 1.03248768e-03
34 RPS4X -0.559187007 13.07139485 1.07387584e-03
35 PDHX -0.876505639 4.69735835 1.19177407e-03
36 ZNF765 -1.273611369 3.92564175 1.23017119e-03
37 ERLEC1 -0.687435084 6.89426820 1.24873155e-03
38 BDNF -0.766056173 5.04354355 1.32309912e-03
39 TPBG 1.141195646 4.32510587 1.40296326e-03
40 EVI2B 2.700400212 1.96996840 1.54514779e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Lapatinib (LAP)
Control Samples: CTRL.3.A1, CTRL.3.B10, CTRL.3.E6, CTRL.3.K4
Drug Samples: LAP.3.A19, LAP.3.B16, LAP.3.E18
Investigative Units: U-13, 15, 19, 25
Sequencing Runs: SR-3
Normalized Counts: Human.D-Hour.48-Plate.3-ReadCounts-Norm-CTRL.LAP.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 TXNIP -1.020541378 7.31567753 2.77911549e-06
2 CYR61 0.820179482 8.42494174 1.12056592e-05
3 IL17RD 1.840008626 4.13738023 6.80415003e-05
4 CBR1 -0.929815132 6.87156875 9.47117991e-05
5 RAC1 -0.741949340 8.77806660 9.67499942e-05
6 ZNHIT1 -0.893525822 6.93019022 1.17066031e-04
7 PRKRIR 1.448817316 4.45948394 3.04005652e-04
8 NID2 1.420162839 4.64954631 3.37021470e-04
9 RRBP1 -1.106741694 5.45623250 4.04949968e-04
10 PDIK1L 1.963778212 3.73577572 4.47152984e-04
11 AKR1C3 -0.845588525 6.65532497 4.58063698e-04
12 SUZ12 1.635945831 4.18640851 4.68416851e-04
13 BHLHE41 -1.188342527 5.18857543 5.84603651e-04
14 RCN3 -0.974882806 6.07517077 5.95511352e-04
15 RASSF3 0.896148297 5.85581556 7.64481834e-04
16 MATN3 2.905829986 3.06940430 8.89802481e-04
17 SLC44A1 1.195322564 4.92268130 9.10356948e-04
18 ADH1B -0.813021831 6.58704809 1.02713879e-03
19 C6orf136 -2.276800678 3.38485385 1.12410108e-03
20 USP10 1.266328996 4.61040141 1.14746080e-03
21 SNX13 1.251651100 4.53722482 1.20050813e-03
22 ANG -0.888145134 5.82246063 1.35657207e-03
23 PCOLCE -0.779244778 6.51643990 1.39266213e-03
24 GNAI2 -0.974836287 5.62815514 1.43147689e-03
25 LCAT -2.575296479 3.23735576 1.54815199e-03
26 ATP13A3 0.630546713 7.72608510 1.70746363e-03
27 PLAC9 -0.724599557 6.99324548 1.73614835e-03
28 CDYL -1.883972183 3.55120481 1.89763887e-03
29 CBX6 -0.696125884 7.07180546 1.96252227e-03
30 AP2S1 -0.658318309 7.53505105 1.99801122e-03
31 SLC4A7 0.874986065 5.98651751 2.02483558e-03
32 NOSIP -1.304121916 4.69970570 2.06608670e-03
33 ATAD2B 1.875647946 3.32484860 2.19278698e-03
34 SNF8 -0.833055875 6.20430361 2.40937199e-03
35 POSTN -0.660905283 6.95052932 2.48997103e-03
36 STXBP5 0.994082157 5.13709722 2.76647576e-03
37 MTMR6 1.187341568 4.38187927 2.78931101e-03
38 UBTF -1.752536612 3.62059745 2.98561349e-03
39 NDUFV1 -1.216283013 4.60132824 3.25522891e-03
40 SEMA6D -3.609842817 2.77001288 3.36203120e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Lapatinib + Ursodeoxycholic acid (LAP+URS)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: LAP+URS.3.D5, LAP+URS.3.D18, LAP+URS.3.P18
Investigative Units: U-17, 18, 12, 23
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.LAP+URS.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPL18 -2.322506726 9.81545729 7.25823763e-36
2 RPLP2 -1.772573000 10.66475914 1.09543162e-23
3 IGFBP5 -1.714008696 8.29185505 1.40182137e-17
4 TXNIP -1.912970315 7.29092500 8.62612958e-15
5 MT2A 1.212238160 9.89384209 7.94235667e-13
6 RPLP1 -1.061833977 12.46656535 4.43730787e-10
7 SLN -1.222620739 7.36197062 9.60916541e-09
8 MT1X 1.335522931 5.83961081 2.75660443e-07
9 MT1F 1.978063350 4.27354877 1.91204460e-06
10 PGK1 -0.830350926 9.69472835 2.52528274e-06
11 LDHA -0.804769229 11.21575125 2.56536583e-06
12 EVI2A 2.007527931 3.82669864 6.55333645e-06
13 RAPGEF5 -1.122744238 6.06589701 1.08153314e-05
14 SCRG1 -1.002659668 6.54039297 1.26109243e-05
15 VAT1 1.313044576 4.83674437 1.27588719e-05
16 TUBA1B -0.757778326 9.98991227 1.39398669e-05
17 DHRS3 1.295124678 5.11564092 1.48137778e-05
18 ENO1 -0.735192500 10.02574368 2.38768114e-05
19 SLC25A39 2.103008580 3.14909451 3.11669477e-05
20 MT1E 1.277252816 5.33533118 3.14122095e-05
21 UFM1 -0.749020091 8.20057070 4.96803837e-05
22 PGAM2 1.278904225 5.32899496 5.08271354e-05
23 P4HA2 -0.708827713 9.23591308 6.35820463e-05
24 NDUFA4L2 -0.786789781 7.38158710 9.51302232e-05
25 YAP1 1.025156296 5.36427413 1.07683985e-04
26 DHX29 -0.878236387 6.15078163 1.12277453e-04
27 IL7 3.818087242 2.03129662 1.27583049e-04
28 ANTXR2 1.031273772 5.53024102 1.34442241e-04
29 P4HA1 -0.758912797 7.25962799 1.56078510e-04
30 DDIT4 -1.982637380 3.57224096 1.78858050e-04
31 PPP1R3C -0.741955898 7.45048246 1.80636669e-04
32 GNPTG 1.511878205 3.89104854 2.00308382e-04
33 DIO2 -1.385831853 4.26920301 2.23832028e-04
34 BNIP3 -0.981663655 5.86794331 2.51301258e-04
35 ANXA2 -0.613021407 11.36036949 3.11039197e-04
36 ARL1 -0.715676482 7.48455352 3.31702848e-04
37 ASPN -0.610560590 10.59569993 3.55825945e-04
38 CNST -0.877015181 6.25251695 4.19658505e-04
39 PUS7L -1.140905509 4.71034830 4.20303178e-04
40 SLFN11 -0.876760475 5.41312104 4.53493608e-04

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Loperamide (LOP)
Control Samples: CTRL.3.A1, CTRL.3.B10, CTRL.3.E6, CTRL.3.K4
Drug Samples: LOP.3.A7, LOP.3.A8, LOP.3.K24
Investigative Units: U-13, 25, 15, 19
Sequencing Runs: SR-3
Normalized Counts: Human.D-Hour.48-Plate.3-ReadCounts-Norm-CTRL.LOP.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 H2AFJ -1.207563919 5.80280945 4.13501149e-05
2 ARMCX2 1.551529615 4.33262710 1.33550016e-04
3 RGS3 -1.117030573 5.64172360 2.24674420e-04
4 ZNHIT1 -0.869872300 6.90642590 2.54718715e-04
5 IGF1 0.832086757 6.65864264 4.48029242e-04
6 B3GALT6 -1.951416584 3.79610616 5.18111387e-04
7 PRELID1 -5.394045474 2.67518652 5.32330244e-04
8 NAP1L4 -1.349584201 4.83502209 5.66686141e-04
9 STAT6 -1.946248233 3.64574469 7.33214906e-04
10 HGS -1.601681765 4.19203603 1.05718485e-03
11 RAC1 -0.665452305 8.77690525 1.23982696e-03
12 HERPUD1 0.769791682 6.72656679 1.31417962e-03
13 COX19 1.322062248 4.46344172 1.38760787e-03
14 NPR3 1.043980690 5.27512095 1.59502155e-03
15 TECPR1 2.298816620 3.10968055 2.16511230e-03
16 SCAF4 2.487974777 3.03459827 2.31415438e-03
17 C1orf112 -3.333978891 2.48559918 2.49364620e-03
18 TP53BP1 1.282766207 4.38819833 2.63475626e-03
19 PRKRIR 1.282459670 4.33775004 2.87285552e-03
20 SIX4 1.609190920 3.68057098 2.88527873e-03
21 SLX4IP 2.080637319 3.16525306 3.05894173e-03
22 ISG15 -1.059660943 4.92205392 3.43932657e-03
23 ALG10B 1.632289766 3.60644736 3.53841842e-03
24 TNFRSF10C 4.643027806 2.23255098 3.54673792e-03
25 IL17RD 1.407327583 3.85011758 3.98191599e-03
26 TMEM147 -1.262245049 4.40262579 4.00571096e-03
27 AHCYL2 2.610947916 2.82913823 4.11674283e-03
28 RRBP1 -0.868595689 5.49530812 4.55221854e-03
29 LAS1L -2.388792683 3.00736540 4.65878504e-03
30 STXBP5 0.932475095 5.07768694 5.10052909e-03
31 COMT -0.585498538 8.45602493 5.12592136e-03
32 PRR16 1.593070435 3.47356729 5.17142162e-03
33 NCBP2-AS2 -3.185644077 2.46064962 5.27021449e-03
34 FAM134B 1.740509324 3.36233784 5.35102220e-03
35 CDR2L 2.067964688 2.94145865 5.42312485e-03
36 ZNF449 -1.793422110 3.30351294 5.48312403e-03
37 PABPC4 -0.944333513 5.08217694 5.50243877e-03
38 SPOP 0.878309606 5.34396299 5.83750248e-03
39 TRIM24 2.759083609 2.62867102 6.15771983e-03
40 IGF2BP1 4.491177491 2.20867053 6.39650717e-03

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line E (LPC-1004)
Drug Treatment: Milrinone (MIL)
Control Samples: CTRL.3.L4, CTRL.3.M4, CTRL.3.M5, CTRL.3.N18
Drug Samples: MIL.3.L7, MIL.3.L8, MIL.3.M9
Investigative Units: U-26, 27, 29
Sequencing Runs: SR-3
Normalized Counts: Human.E-Hour.48-Plate.3-ReadCounts-Norm-CTRL.MIL.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPS9 1.722163455 10.27017856 4.21468353e-25
2 ACTA2 -1.151340345 13.63185295 3.35476815e-12
3 TUBA1B -1.043470325 10.27034526 7.78846250e-10
4 IGFBP5 1.045900723 8.47212462 3.94716230e-09
5 ADH1B 0.889225347 9.88861445 7.29092306e-08
6 MAP3K7CL -0.934734159 8.54308735 3.44388236e-07
7 MYL12A -0.837320523 11.11977667 5.01195986e-07
8 ASPN 0.811942827 11.07148294 5.39463390e-07
9 COL3A1 0.807626410 10.58178318 7.19312113e-07
10 FAM13C 1.142181602 6.52407217 7.63990442e-07
11 TPM2 -0.908604343 8.22078239 1.47276879e-06
12 TAGLN -0.835185145 9.40762777 1.47768214e-06
13 DHRS3 -1.406239876 5.70622522 3.35450919e-06
14 ANKRD1 -1.278888919 5.87626852 4.60618928e-06
15 SULF1 -0.987875765 6.99933011 6.99285566e-06
16 ANGPT1 0.987709815 6.75334895 7.31012605e-06
17 GNG11 0.792662743 8.31029034 1.06067505e-05
18 SERPINE1 -0.899813750 7.46066022 1.07021775e-05
19 SH3BGR -1.091622204 6.05058964 1.56941121e-05
20 ABI3BP 0.901876676 6.95169582 1.63988395e-05
21 IDI1 -0.760223647 8.81308352 1.70861514e-05
22 IFI27 -1.280988293 5.80113921 1.87626975e-05
23 PTN 0.944988670 6.73064896 2.01084185e-05
24 IFITM1 0.721335601 9.11857258 2.20336967e-05
25 MSMO1 -0.726710749 9.27883775 2.28857098e-05
26 SCRG1 -1.157416216 5.94079819 2.68831267e-05
27 FABP3 -1.250290434 5.43924015 2.92865591e-05
28 SAT1 0.768888223 7.80688383 3.16287762e-05
29 LBH -0.807176353 7.73596054 3.30751971e-05
30 CALD1 -0.680848186 12.05870090 3.33253814e-05
31 IGFBP4 0.872675523 6.81463527 3.85587209e-05
32 ABCA1 0.846075619 7.03064696 4.55294694e-05
33 RPLP1 -0.668453926 12.05387447 4.63650827e-05
34 SLC40A1 0.726006324 8.40367145 5.49204769e-05
35 LHFP 0.835276532 7.25214124 5.56004445e-05
36 LAMA4 1.015482161 6.11189652 7.55696489e-05
37 TUBA1A -0.678063456 9.40296666 8.69996281e-05
38 PLAG1 1.907040874 3.94473438 9.19228929e-05
39 CYBRD1 0.726379160 7.94438380 1.05991853e-04
40 MYH10 -0.728434809 8.11301454 1.20774540e-04

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Methotrexate (MTX)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: MTX.3.B8, MTX.3.C9, MTX.3.G2
Investigative Units: U-14, 16, 20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.MTX.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RPS9 -1.227129517 9.89720157 2.97250990e-19
2 RPL18 -1.142259887 8.59942935 1.80915430e-14
3 RPL28 -0.847821369 9.75919047 4.25015923e-10
4 PICALM 1.217610529 5.61472301 8.04110925e-08
5 RPF2 -1.019220978 6.56669275 1.33222457e-07
6 RPS23 -0.650780376 13.15797944 2.28490800e-07
7 AHNAK 0.781200005 7.61479946 3.25785667e-07
8 RPLP1 -0.646010328 12.10124399 3.65428651e-07
9 CYR61 0.767751427 7.46452469 1.01184445e-06
10 FTL -0.603678398 14.26943333 1.26810530e-06
11 PLA2G16 -0.723133337 7.56842415 6.94357046e-06
12 RPS28 -0.596439698 9.49384722 1.18111091e-05
13 LOC100505738 -0.755174709 7.12328841 1.42936803e-05
14 RPLP2 -0.580322484 9.60041269 1.72989691e-05
15 RPS24 -0.535162652 11.66892655 2.63415071e-05
16 ZFAS1 -0.551044398 10.16097540 2.85165916e-05
17 RGS5 0.653437519 7.36442530 3.31405588e-05
18 RAD23B 0.930914474 5.59689725 3.76899125e-05
19 TXNRD1 -0.591837411 8.69147424 3.86593826e-05
20 RGS2 -1.231992878 5.05458896 4.03850183e-05
21 CLEC2B -0.653560190 7.61770314 4.73885889e-05
22 LTA4H -0.617504982 7.92217824 5.89241386e-05
23 COL4A1 0.573749547 8.28500404 5.92635570e-05
24 TIMP1 -0.510557327 11.59798284 5.97356226e-05
25 RPL10 -0.501519738 12.99897646 6.22237473e-05
26 SUCLG1 -0.683920477 7.16403171 7.05104436e-05
27 AKR1C3 -0.677537183 7.25072259 7.26268202e-05
28 NUCKS1 0.590330937 7.84347016 7.71904234e-05
29 PSMA1 -0.562988426 8.70624679 8.00282943e-05
30 SH3PXD2A 0.625742456 7.23038302 1.10595400e-04
31 C12orf57 -0.689270383 6.94136793 1.20629408e-04
32 EIF6 -0.714307419 6.73909023 1.26825712e-04
33 RPL10A -0.487357443 11.62203787 1.27131752e-04
34 RPL37A -0.481324449 11.68641118 1.48589974e-04
35 SDHAF2 -0.759249334 6.32019726 1.57618260e-04
36 PSMB2 -0.547210077 8.38805252 1.98587846e-04
37 RPL38 -0.482712252 10.49041393 2.06724852e-04
38 AK2 -0.904832070 5.54519397 2.12164526e-04
39 ATP13A3 0.548427623 7.88060478 2.24656092e-04
40 CHID1 -0.727306186 6.27413000 2.38012973e-04

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Pazopanib (PAZ)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: PAZ.3.F19, PAZ.3.H22, PAZ.3.J24
Investigative Units: U-20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.PAZ.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 PLIN2 4.11656014 10.70958268 2.68942136e-157
2 MT1X 4.38179412 7.99110105 5.00531918e-121
3 C5orf46 -3.26766731 9.40646531 6.78023357e-70
4 MT2A 2.61924147 10.25797808 2.08387223e-69
5 MT1E 3.77224597 6.48707272 2.53297638e-65
6 PTX3 2.73470813 7.86346891 9.63620125e-58
7 EVI2A 3.34991041 6.57444706 9.85736812e-57
8 C10orf10 2.70854191 7.80450091 4.15762965e-56
9 COL1A1 -2.44375341 11.07937678 1.67789694e-49
10 CTGF -2.52123856 8.77265903 3.79887699e-44
11 DDIT3 2.09193629 9.59348984 4.33746169e-44
12 CYP1B1 3.55996509 5.71475111 6.81637705e-43
13 TUBA1B -2.31763282 9.87941300 1.44000730e-42
14 TUBA1A -2.43931853 8.70593715 1.06406389e-41
15 GDF15 2.43701081 6.77239110 6.89172565e-37
16 KRT18 -2.55945141 7.35081383 6.90379880e-36
17 COL1A2 -2.00463988 11.06660504 2.23559021e-35
18 MT1F 4.68038133 4.78126805 2.69831347e-35
19 SERPINE2 -2.03068915 9.92468190 9.43364991e-35
20 ANKRD1 -3.38120794 6.06905532 2.60657220e-34
21 LDHA -1.95219205 10.82043028 1.37302760e-33
22 TIMP3 -2.03713399 8.90069542 9.26529505e-32
23 PGK1 -1.90118251 9.97456996 3.10416285e-31
24 LRRC17 -2.53279486 6.84334326 2.32374943e-30
25 TXNIP -2.26153548 7.31730214 2.89734720e-29
26 P4HA1 -2.13006806 7.78021814 2.95818625e-29
27 IDH1 1.74755937 8.62402937 3.20652494e-29
28 TNFRSF11B -1.91779833 9.06067408 3.57616546e-29
29 SERPINE1 -2.02376002 7.96580285 9.42176575e-28
30 HMGB2 1.63683710 8.99492454 1.02790707e-26
31 IGFBP3 -1.69701344 10.11973641 7.55329267e-26
32 IFRD1 1.96752248 6.74971187 2.06541874e-25
33 VCAM1 -3.47732483 5.30170185 4.88054733e-25
34 HAPLN1 -2.42100908 6.38254571 7.00861618e-25
35 TAGLN -1.69824604 9.36052357 1.26344947e-24
36 SLC3A2 2.12756559 6.22016107 1.60924405e-24
37 MAGED1 -2.21594276 6.59914242 2.37625275e-23
38 GADD45A 1.79950218 7.04148844 2.81968628e-23
39 CCL11 -2.12092454 6.63083805 3.39669458e-22
40 KDELR3 -2.30426547 6.20985359 4.23445630e-22

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Ruxolitinib (RUX)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: RUX.3.F20, RUX.3.H23, RUX.3.K1
Investigative Units: U-20, 22, 24, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.RUX.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 CCL2 -2.020606788 7.59668864 1.62770217e-28
2 CCL11 -1.805896349 6.68178843 1.94768464e-17
3 NNMT -1.221196145 7.67405881 4.23831147e-13
4 PTK7 2.205617546 4.38201720 9.73079912e-11
5 RPS9 -0.862816832 9.93834372 2.14020371e-10
6 SDPR 1.009829461 6.97964737 2.86002245e-09
7 IFITM3 -0.878752630 8.46569629 5.04411306e-09
8 SORBS2 1.220029922 5.71133400 3.91241960e-08
9 SCG2 -1.045520950 6.41901535 2.21804069e-07
10 VWA5A -2.263981300 4.23676679 2.93985723e-07
11 RPL18 -0.748005744 8.65031490 2.99792882e-07
12 CRYAB 0.621796350 10.18292778 1.36045275e-06
13 PLIN2 -0.752939593 7.63211516 5.10481915e-06
14 ANK3 1.172758644 5.18553191 5.42183167e-06
15 TAGLN -0.618799713 9.57524966 7.07863303e-06
16 CAPN6 2.969061042 2.82080320 7.36548028e-06
17 MYH10 0.581629502 9.75398237 9.37013080e-06
18 IFITM2 -0.699508634 7.68372808 1.85064741e-05
19 CCDC146 1.146908425 5.07223257 2.27785559e-05
20 C1R -0.712491149 7.40358118 2.73734051e-05
21 RBM15B 1.645044380 3.92163529 2.80652768e-05
22 S100A4 0.543458804 9.99249693 2.94843699e-05
23 DKK1 0.993671478 5.49425784 3.13595809e-05
24 RAC1 -0.582789053 8.66829306 4.42552865e-05
25 CTGF 0.540672931 9.51959584 4.92336469e-05
26 ST3GAL2 1.603103683 3.84242573 6.12009990e-05
27 GCHFR 1.251677907 4.53582142 6.29886233e-05
28 PLCE1-AS1 2.034376416 3.22226457 6.86673037e-05
29 CSF2RB 1.840282554 3.44072667 7.62057361e-05
30 ENO1 -0.520835473 10.44352417 8.04463255e-05
31 UBE2T -1.758890958 4.13285864 8.34344129e-05
32 CDK5RAP2 -1.170665033 5.01574225 1.01284111e-04
33 ATP10D 0.763321521 6.20911999 1.07322365e-04
34 SERPINE2 -0.511984174 10.21691639 1.18050908e-04
35 TSC22D1 0.806494852 5.92883071 1.19539257e-04
36 RPL22L1 -0.920254953 5.75278911 1.21109570e-04
37 MGST1 -0.540966805 9.13454084 1.24852606e-04
38 NPR3 0.610403110 7.45565475 1.25322169e-04
39 SLC2A3 -0.822607765 6.15180544 1.27707800e-04
40 TSPAN8 1.733350415 3.53562292 1.38580918e-04

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sorafenib (SOR)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: SOR.3.B20, SOR.3.H13, SOR.3.J14
Investigative Units: U-16, 22, 24, 20, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.SOR.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 PLIN2 3.90343368 10.53599933 1.81435212e-190
2 FGF7 -5.00797546 8.23096197 1.00824249e-118
3 TAGLN -3.62675032 9.20279200 1.16111798e-100
4 MYH10 -3.60444443 8.93525371 2.19639121e-95
5 IGFBP3 -3.08862822 9.99133770 5.19407090e-88
6 TIMP3 -3.33740274 8.80570471 1.13370721e-84
7 TNFRSF11B -3.23270163 8.95354665 5.78664562e-83
8 C5orf46 -3.06757910 9.43885089 1.02440624e-81
9 ACTA2 -2.52731342 12.42675198 2.97823851e-72
10 CTGF -3.01483435 8.75516249 4.38443327e-72
11 SUPV3L1 3.86046827 6.25699737 2.79884462e-69
12 HSPA5 2.23614700 10.46107655 4.66801416e-69
13 COL1A1 -2.39851374 11.10511015 5.17127340e-64
14 MT2A 2.14714865 9.92014051 5.18760223e-62
15 SERPINE2 -2.45024071 9.89808930 2.40944332e-60
16 IGF1 -2.84262040 8.17144366 4.79582442e-60
17 KRT18 -3.29344352 7.31903874 1.71664948e-58
18 S100A10 -2.54402867 8.99869324 1.76731915e-58
19 CALD1 -2.20259215 10.61211626 1.87207552e-54
20 CAV1 -2.36810189 9.26018775 4.75357679e-54
21 CDH11 -3.20400849 7.11947628 2.05976544e-53
22 ACTG1 -2.24612908 9.94979401 7.95722217e-53
23 TIMP1 -2.12483175 11.27473424 1.81253989e-52
24 KIAA1199 -3.13786473 6.97278872 8.43863513e-50
25 ACTB -2.15189228 9.62938394 8.44166944e-48
26 LDHA -2.00429887 10.83283593 7.31146561e-47
27 LUM -2.01455831 10.36891495 2.37877798e-46
28 MGP -1.95479111 10.18613450 1.55662660e-43
29 ANKRD1 -4.00416217 6.06763358 2.71232277e-43
30 STK17B -3.03623904 6.65631568 1.56422310e-42
31 SEPT11 -2.37496144 7.75935262 7.69348356e-42
32 COL3A1 -2.08291087 8.78341887 3.48630276e-41
33 TPM2 -2.20394817 8.18897101 4.93149126e-41
34 CCL11 -3.06424211 6.56454698 6.06121555e-41
35 NPR3 -2.92709841 6.66016432 1.03436554e-40
36 ANXA2 -1.83785206 11.06810083 1.34662082e-40
37 SGK1 -2.50331431 7.31380240 2.10296084e-40
38 MYL6 -1.79829110 12.42415320 2.43474899e-40
39 PTGIS -2.57467600 7.12626231 6.34718775e-40
40 GDF15 2.33600118 6.71246744 1.00165846e-39

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Sorafenib (SOR)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: SOR.3.C24, SOR.3.D13, SOR.3.D15, SOR.3.G5
Investigative Units: U-17, 18, 21, 23, 12
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.SOR.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 ACTA2 -2.89459572 13.54398608 3.58742993e-78
2 RGS4 -3.22155814 7.66688769 2.81470092e-71
3 TNFRSF11B -2.71557582 9.57905809 2.36330283e-68
4 PLIN2 2.86039921 8.79299490 1.94925880e-67
5 MYH11 -3.34321716 6.61643380 3.72726174e-55
6 SLN -3.00133322 6.98829352 1.48174742e-54
7 RPL18 -2.35898207 9.76362795 1.04557980e-53
8 IGFBP5 -2.52474141 8.09450793 3.25282455e-52
9 MSMO1 -2.35618779 8.89615612 5.07987472e-50
10 LDHA -2.21267279 10.87964382 4.07466242e-49
11 TUBA1A -2.30728520 8.91534642 1.02836268e-48
12 HMGCS1 -3.56558995 5.95690697 7.02750746e-45
13 PTX3 2.25287608 8.38629977 4.15418357e-44
14 IDI1 -2.21693789 8.39590906 1.49236476e-43
15 FGF7 -2.78942038 6.61633828 2.52589749e-43
16 TIMP1 -2.05245146 11.61669409 6.03055955e-43
17 SCD -2.66722206 6.75601360 6.73414986e-42
18 ANKRD1 -2.51233020 6.94810250 2.24049578e-41
19 C5orf46 -2.08779771 8.14773011 6.91356198e-39
20 SUPV3L1 3.15365491 6.29369663 2.02598645e-38
21 GADD45A 2.35558346 7.36914817 3.66459565e-37
22 UACA -1.98737611 8.71066538 4.90713864e-37
23 MYH10 -1.98974808 8.53702024 2.60533433e-36
24 RPLP2 -1.86873292 10.63289888 4.60017092e-36
25 MGP -1.83801987 11.25524894 3.50343470e-35
26 TXNIP -2.19980692 7.14055636 8.85212020e-35
27 TAGLN -1.85070394 9.11679634 6.13800064e-34
28 STK38L -2.16129049 7.02797885 3.27489147e-33
29 MYL6 -1.76712103 12.63909742 7.84141891e-33
30 S100A10 -1.92207977 7.96689470 1.24640268e-32
31 LUM -1.77046007 9.58814414 6.16750985e-32
32 COL1A1 -1.71791315 11.03026315 4.18873074e-31
33 ACTB -1.72880822 9.89405387 9.12524559e-31
34 CALD1 -1.70246617 12.03980127 9.73394962e-31
35 PLS3 -1.73115399 9.56974607 1.27162275e-30
36 NPTN -1.97401425 7.25342579 5.99110515e-30
37 VCAN -1.73079486 8.91319247 1.14063176e-29
38 RGS5 -1.70151162 9.19672766 2.84004987e-29
39 CA3 -3.00827479 5.29676780 2.88204591e-28
40 CAV1 -1.61194184 9.78384961 4.16676843e-27

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Sorafenib + Diethylpropion (SOR+DTP)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: SOR+DTP.3.D12, SOR+DTP.3.D22, SOR+DTP.3.G10
Investigative Units: U-17, 18, 21, 23, 12
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.SOR+DTP.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 PLIN2 3.06162772 8.73509380 6.23063638e-55
2 RGS4 -3.03230593 7.78406082 1.14034229e-40
3 MYH11 -3.49146537 6.71292513 3.17735226e-38
4 GADD45A 2.67210319 7.42742142 1.30775205e-35
5 ACTA2 -2.44811411 13.67637797 1.67074272e-35
6 MSMO1 -2.51001711 8.94723696 2.02006654e-34
7 IGFBP5 -2.49300470 8.17758013 4.00548863e-32
8 TNFRSF11B -2.31836849 9.70831614 3.08170376e-31
9 RPL18 -2.17416687 9.85922198 9.46679889e-29
10 SLN -2.57704991 7.13046082 2.40021530e-28
11 SUPV3L1 3.08223545 6.02833662 2.55924792e-28
12 HMGCS1 -3.15483815 6.09237803 1.08165374e-27
13 SCD -2.66231133 6.84511411 1.31439205e-27
14 SNHG1 2.89385890 5.73777883 8.78155638e-27
15 MT1E 2.61277003 6.36919394 6.28528265e-26
16 PTX3 2.01537545 7.99796738 2.11643474e-25
17 MT1F 3.26511602 5.36627830 2.64782183e-24
18 IDI1 -2.04043850 8.48846333 6.02383802e-24
19 LDHA -1.89927417 10.99277336 4.15329756e-23
20 TUBA1A -1.94915028 9.03804109 7.82908614e-23
21 UACA -1.93462377 8.77712264 3.72108126e-22
22 MYH10 -1.91355411 8.60552114 1.95164970e-21
23 ANKRD1 -2.18472319 7.07235442 2.07331156e-21
24 HMGCR -2.39081320 6.39666828 2.79924558e-21
25 FGF7 -2.21584614 6.77664029 3.04383935e-20
26 COL1A1 -1.71769644 11.07280719 1.73241009e-19
27 RPLP2 -1.69984292 10.71243061 3.91043297e-19
28 STK38L -1.99051968 7.12735588 4.04673547e-19
29 TIMP1 -1.68820828 11.73622401 5.81189291e-19
30 TSLP 1.98484179 6.88939386 1.02499698e-18
31 SYNPO2 -1.91940854 7.27618118 2.30519602e-18
32 GDF15 2.10774894 6.03653508 6.22425472e-18
33 SLC3A2 2.06985927 6.19295837 1.72840952e-17
34 LBH -1.77610073 7.61020251 2.13367636e-17
35 SLC40A1 -2.01791446 6.72632007 2.15294219e-17
36 TXNIP -1.84582360 7.26894485 5.43426268e-17
37 RAPGEF5 -2.32617392 5.82844181 7.73933646e-17
38 C5orf46 -1.65962810 8.28720653 1.29901780e-16
39 RAB32 1.83617599 6.57631365 1.52654733e-16
40 C10orf10 1.80323069 6.82431982 2.96371710e-16

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sorafenib + Entecavir (SOR+ENT)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: SOR+ENT.3.B22, SOR+ENT.3.H17, SOR+ENT.3.J17
Investigative Units: U-16, 22, 24, 20, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.SOR+ENT.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 PLIN2 3.87137876 10.49542276 1.39187650e-161
2 FGF7 -4.60648107 8.22853467 4.77830659e-97
3 TAGLN -3.70497557 9.18769721 1.48752813e-90
4 SUPV3L1 4.14997657 6.49645521 7.91954452e-77
5 MYH10 -3.36109612 8.93547623 4.67820511e-76
6 TNFRSF11B -3.04319130 8.95497214 4.09581582e-66
7 C5orf46 -2.91268123 9.43759272 6.12537658e-66
8 IGFBP3 -2.80299637 9.99935607 7.66861743e-66
9 TIMP3 -2.82970017 8.82765249 2.67463891e-58
10 ACTA2 -2.42796661 12.42473412 2.85386342e-58
11 IGF1 -2.99492249 8.14822056 1.31865349e-56
12 KRT18 -3.52704439 7.29500875 2.33672892e-56
13 CTGF -2.72928796 8.76425683 8.52055673e-55
14 S100A10 -2.57524155 8.98434522 1.03162867e-51
15 HSPA5 2.07760126 10.33393023 1.16253229e-51
16 COL1A1 -2.27471446 11.10579897 1.51691744e-50
17 CALD1 -2.17010442 10.60393423 7.99083530e-46
18 ACTG1 -2.22052166 9.94035748 5.32944062e-45
19 CAV1 -2.30646849 9.25535141 7.03501861e-45
20 TIMP1 -1.96954391 11.28217488 9.07353993e-40
21 LDHA -1.95098282 10.82829464 1.38526048e-38
22 LRRC17 -2.90301352 6.82064503 1.76530720e-38
23 MT2A 1.81608071 9.67543189 1.90036510e-38
24 LUM -1.95496032 10.36482423 5.78317531e-38
25 CDH11 -2.68950174 7.14614046 6.09907374e-38
26 TPM2 -2.24349043 8.17301703 5.18841793e-37
27 NPR3 -2.95078488 6.64852690 9.67302699e-37
28 ACTB -1.99225869 9.63688324 1.34059363e-36
29 KIAA1199 -2.68672381 6.99607019 1.36835881e-36
30 PTX3 2.10171255 7.39247162 7.77152968e-36
31 GDF15 2.32214850 6.69233844 4.38823916e-35
32 SERPINE2 -1.85201259 9.95699608 8.09173803e-34
33 TUBA1A -1.99721665 8.76313780 1.71056505e-33
34 MYL6 -1.75043922 12.41932135 2.58804632e-33
35 MGP -1.80100086 10.19557780 9.88629299e-33
36 ANXA2 -1.75811173 11.06786454 1.77219204e-32
37 STK17B -2.66698134 6.67358962 1.82875389e-32
38 SGK1 -2.34027165 7.32005156 2.07766341e-32
39 CCL11 -2.72799917 6.58031862 4.11281807e-32
40 TMEM71 6.21227180 4.26544853 1.74517740e-31

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Sorafenib + Entecavir (SOR+ENT)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: SOR+ENT.3.D10, SOR+ENT.3.D20, SOR+ENT.3.G8
Investigative Units: U-17, 18, 21, 23, 12
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.SOR+ENT.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 RGS4 -3.20991377 7.79351618 2.28619204e-46
2 PLIN2 2.67893247 8.44482444 4.89143016e-44
3 MYH11 -3.51221940 6.73717966 2.04655896e-39
4 ACTA2 -2.55078256 13.69403509 3.89179950e-38
5 TNFRSF11B -2.56604368 9.70731470 1.73912297e-37
6 SLN -2.96348236 7.11691059 1.45523544e-35
7 IGFBP5 -2.53503011 8.20258697 1.67145468e-33
8 ANKRD1 -2.84506625 7.02209833 1.94535046e-32
9 MSMO1 -2.36574439 8.99204700 2.63024813e-32
10 RPL18 -2.29678974 9.86991534 3.90597647e-32
11 PTX3 2.12200096 8.11026386 9.07524333e-29
12 HMGCS1 -2.97149133 6.12128075 5.00564341e-28
13 GADD45A 2.32395760 7.18360033 2.13737402e-27
14 IDI1 -2.16910381 8.49673437 2.85100117e-27
15 MT1E 2.61373869 6.40291525 9.19713154e-27
16 SCD -2.39826517 6.89711948 2.66667836e-25
17 TUBA1A -2.04618254 9.05190080 3.28639056e-25
18 MT1F 3.17991315 5.33889908 1.70680488e-23
19 LDHA -1.90571788 11.02115956 1.77227134e-23
20 RPLP2 -1.85939304 10.71341572 1.50621707e-22
21 C5orf46 -1.96291116 8.26352203 3.33901481e-22
22 SUPV3L1 2.72351084 5.77502069 6.32564468e-22
23 TIMP1 -1.78000229 11.74921579 6.83627425e-21
24 TAGLN -1.83016574 9.20117931 7.61022824e-21
25 STK38L -2.06066946 7.14452380 1.46148461e-20
26 SLC40A1 -2.17314744 6.72549542 1.94622420e-20
27 RGS5 -1.77427669 9.25461314 2.34383156e-20
28 SNHG1 2.50846120 5.46950280 3.31269411e-20
29 INSIG1 -3.64097418 4.73911084 7.44613877e-20
30 HMGCR -2.14408534 6.45044527 2.37747584e-19
31 FGF2 1.99544033 6.15531727 2.08646257e-18
32 FGF7 -2.04337452 6.83258640 3.99129265e-18
33 UACA -1.68616522 8.85070803 6.54117794e-18
34 MYH10 -1.69538293 8.67378649 7.40745246e-18
35 LOC100507254 -2.52947217 5.74456439 9.69694252e-18
36 COL1A1 -1.61278793 11.12239573 1.14250641e-17
37 MGP -1.60470379 11.37643994 1.74052298e-17
38 SRXN1 2.91847224 4.62833023 1.84260798e-17
39 GDF15 2.03012947 6.01557646 2.03333071e-17
40 LBH -1.74518394 7.64410023 2.39897259e-17

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line A (LPC-1001)
Drug Treatment: Sorafenib + Ursodeoxycholic acid (SOR+URS)
Control Samples: CTRL.3.F6, CTRL.3.H5, CTRL.3.J4, CTRL.3.J18, CTRL.3.O14
Drug Samples: SOR+URS.3.B21, SOR+URS.3.H14, SOR+URS.3.J15
Investigative Units: U-16, 22, 24, 20, 8
Sequencing Runs: SR-3
Normalized Counts: Human.A-Hour.48-Plate.3-ReadCounts-Norm-CTRL.SOR+URS.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 PLIN2 3.86397260 10.50591566 1.35587672e-120
2 FGF7 -4.88746535 8.22688690 8.71970042e-92
3 SUPV3L1 4.09133683 6.47379217 1.12217399e-67
4 TAGLN -3.49247843 9.20585113 1.54988923e-67
5 MYH10 -3.37492032 8.94038239 5.02484521e-63
6 MT2A 2.62550309 10.28398497 2.08800460e-60
7 TIMP3 -3.24781478 8.80289800 4.02459922e-59
8 TNFRSF11B -3.21656008 8.95152863 6.90289653e-59
9 C5orf46 -3.10742025 9.43415903 5.16078959e-58
10 IGFBP3 -2.82718191 10.00483322 1.42199486e-51
11 HSPA5 2.36154062 10.55343971 6.20860863e-50
12 KRT18 -3.41371605 7.30020368 2.03627532e-49
13 CTGF -2.86449505 8.75770304 9.01475096e-49
14 IGF1 -2.97533259 8.15441358 5.20410120e-48
15 GDF15 2.70065632 7.00339243 1.22489560e-43
16 SLC3A2 2.79315082 6.74505640 3.11665764e-43
17 ACTA2 -2.46240548 12.43235887 3.25018537e-43
18 COL1A1 -2.46682112 11.09409201 4.00153139e-43
19 LRRC17 -3.31473797 6.79114866 7.68156793e-42
20 CDH11 -2.94258936 7.12390968 1.57614645e-39
21 S100A10 -2.46834707 9.00242166 2.52245294e-39
22 SERPINE2 -2.37744921 9.89931290 4.44154293e-39
23 TIMP1 -2.22481786 11.26088211 2.64005509e-36
24 KIAA1199 -2.86538849 6.98129763 3.87272480e-36
25 CAV1 -2.26497341 9.26805934 8.27727246e-35
26 ANKRD1 -3.46999371 6.07041926 1.73949215e-34
27 CALD1 -2.15485676 10.61446855 3.35696989e-34
28 SGK1 -2.55256269 7.29914109 2.05024515e-33
29 EAF2 3.19171028 5.58393915 2.53634177e-33
30 NPR3 -2.83888444 6.65015074 6.84247082e-33
31 STK17B -2.77365625 6.65965508 1.14249950e-31
32 ATF3 4.37338355 4.77664521 1.36844508e-31
33 TMEM71 6.22310448 4.31160358 2.69218553e-31
34 THBS1 -2.19358132 8.15994275 1.64660517e-30
35 ACTG1 -2.02129470 9.97207217 2.24741686e-30
36 CCL11 -2.70737760 6.57678651 3.05022545e-30
37 PLAC9 -2.67134339 6.68665913 3.17903683e-30
38 COL3A1 -2.10788103 8.77352149 3.89133307e-30
39 SEPT11 -2.21643134 7.76668777 2.57895222e-29
40 CTH 3.24331170 5.28923566 4.99686683e-29

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line B (LPC-1002)
Drug Treatment: Sorafenib + Ursodeoxycholic acid (SOR+URS)
Control Samples: CTRL.3.D14, CTRL.3.I5, CTRL.3.P4, CTRL.3.P5
Drug Samples: SOR+URS.3.D1, SOR+URS.3.D16, SOR+URS.3.G6
Investigative Units: U-17, 18, 21, 23, 12
Sequencing Runs: SR-3
Normalized Counts: Human.B-Hour.48-Plate.3-ReadCounts-Norm-CTRL.SOR+URS.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 PLIN2 2.97273213 8.69513290 1.19218922e-59
2 RGS4 -3.45001219 7.77320765 1.46927544e-57
3 TNFRSF11B -3.05705411 9.65864227 6.64886236e-57
4 ACTA2 -2.75987027 13.67367799 4.47881308e-50
5 SLN -3.15333763 7.09521604 3.64849341e-43
6 MT1F 3.86064814 5.92544717 2.33882291e-41
7 MYH11 -3.09410648 6.75701194 1.75704297e-38
8 IGFBP5 -2.53208366 8.19911314 3.70374108e-38
9 RPL18 -2.32928984 9.86757254 2.68512622e-37
10 MSMO1 -2.40014191 8.98849299 3.15067367e-37
11 GADD45A 2.52490257 7.34318062 1.00733719e-35
12 PTX3 2.24710236 8.21192862 1.07369625e-35
13 TUBA1A -2.30531698 9.01335160 5.27067037e-35
14 LDHA -2.17506325 10.98061950 1.09848953e-33
15 C5orf46 -2.29538455 8.20836879 5.12857136e-33
16 SCD -2.66785182 6.86028506 1.44827613e-32
17 MT1E 2.71621635 6.49009454 1.51766754e-31
18 HMGCS1 -3.09572130 6.10702591 2.14238046e-31
19 IDI1 -2.17688335 8.49595599 1.06993882e-30
20 ANKRD1 -2.47385499 7.05298985 1.63975031e-30
21 MYH10 -2.06746728 8.60699072 1.72633432e-28
22 COL1A1 -1.97032947 11.06012328 2.15653497e-28
23 UACA -2.04920042 8.78566679 2.29979194e-28
24 TXNIP -2.29438271 7.21931989 5.84077737e-28
25 MT1X 2.35711139 6.67908168 6.27327515e-27
26 SUPV3L1 2.88248561 5.90386069 6.68725637e-27
27 CA3 -3.34078748 5.36901546 9.07021687e-27
28 FGF7 -2.33512141 6.77421919 3.48535811e-26
29 TIMP1 -1.86455697 11.73596697 7.04315560e-26
30 RPLP2 -1.86345577 10.71399188 9.42110204e-26
31 SLC3A2 2.32212182 6.42664986 2.80122515e-25
32 IGFBP3 -1.90313401 8.98136750 3.18826104e-25
33 SNHG1 2.63651320 5.58777698 2.36276914e-24
34 STK38L -2.07789873 7.13129534 6.24131716e-24
35 PLS3 -1.79968335 9.63044224 7.18013551e-24
36 MYL6 -1.77514078 12.71361366 9.90723146e-24
37 RAPGEF5 -2.62269757 5.79686332 2.22561370e-23
38 LEP -3.32624019 4.98847059 6.40633910e-23
39 RGS5 -1.76065089 9.25785622 1.04889891e-22
40 MGP -1.71916466 11.35591984 1.85103519e-22

Release Date: August 20, 2015
Cell Line: PromoCell Cardiomyocyte, Line D (LPC-1003)
Drug Treatment: Sorafenib + Ursodeoxycholic acid (SOR+URS)
Control Samples: CTRL.3.A1, CTRL.3.B10, CTRL.3.E6, CTRL.3.K4
Drug Samples: SOR+URS.3.A18, SOR+URS.3.E9, SOR+URS.3.K6
Investigative Units: U-13, 19, 25, 15
Sequencing Runs: SR-3
Normalized Counts: Human.D-Hour.48-Plate.3-ReadCounts-Norm-CTRL.SOR+URS.txt

Rank Gene Log(Fold-Change) Log(Count/Million) p-Value
1 GDF15 3.60138884 7.59708906 1.09761444e-31
2 ACTA2 -3.26116660 13.72741538 1.47638474e-30
3 DDIT3 2.82909132 10.62288367 2.89101100e-27
4 TNFRSF11B -3.15312633 8.62635912 4.35994793e-25
5 HSPA1A 3.69930956 6.47809265 2.20705256e-24
6 PLIN2 2.76443604 8.86788302 3.54651212e-24
7 SLC3A2 3.25046370 6.98821385 3.98600606e-24
8 PTX3 2.85273081 8.31144862 5.05782498e-24
9 HSPA1B 4.54498518 5.78398540 1.16798803e-23
10 GNG2 4.52442614 5.54336352 2.00213839e-23
11 MT1X 2.82991497 7.79947213 3.93338000e-22
12 C10orf10 2.76426030 7.26724679 3.68014476e-20
13 DNM3OS -3.08235914 6.86696242 2.04238927e-19
14 MYH10 -2.61634542 8.89402825 2.71075720e-19
15 DNAJB1 3.32658466 5.88441129 3.93138314e-18
16 MT1E 2.60364749 7.12995034 4.78078216e-18
17 SUPV3L1 3.16332592 5.89195570 2.51681520e-17
18 SNHG1 3.08662892 6.07602427 4.82754874e-17
19 ZFP36L1 2.25170999 8.13432362 4.48251021e-16
20 IRF2BP2 2.37717091 7.38330066 6.03723901e-16
21 DUSP1 3.57691094 5.31090831 6.88284285e-16
22 SAT1 2.10549607 9.04310379 1.51037574e-15
23 PLAC9 -2.80720985 6.54231984 1.90745944e-15
24 COL1A1 -2.15413124 11.29769872 1.98949061e-15
25 RND3 2.08418313 9.12700324 2.93529880e-15
26 HMGB2 2.03725405 9.53663717 4.90888051e-15
27 MYC 3.02983321 5.49494019 2.79598383e-14
28 ARRDC3 2.17770057 7.61064079 3.19716666e-14
29 C5orf46 -2.27342066 7.96093660 3.78780892e-14
30 PGK1 -2.12313868 9.24885034 4.85239642e-14
31 MIR143HG -2.67200834 6.52977866 7.58277101e-14
32 ITPRIP 2.76647198 5.91124733 1.05069472e-13
33 GADD45A 2.09646849 7.35472646 4.08772279e-13
34 CDKN1A 2.23522862 6.69797317 7.04666795e-13
35 IFRD1 2.17448397 6.86480195 8.15118994e-13
36 SLN -2.02099806 8.90449749